Amino acid dipepetide frequency for Streptococcus phage V22

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.078AlaAla: 3.078 ± 0.813
0.187AlaCys: 0.187 ± 0.129
5.876AlaAsp: 5.876 ± 0.634
6.249AlaGlu: 6.249 ± 0.766
3.078AlaPhe: 3.078 ± 0.753
5.13AlaGly: 5.13 ± 0.852
0.466AlaHis: 0.466 ± 0.227
4.757AlaIle: 4.757 ± 0.817
5.596AlaLys: 5.596 ± 0.846
6.995AlaLeu: 6.995 ± 0.882
2.518AlaMet: 2.518 ± 0.437
3.358AlaAsn: 3.358 ± 0.627
1.772AlaPro: 1.772 ± 0.398
2.798AlaGln: 2.798 ± 0.44
2.705AlaArg: 2.705 ± 0.518
2.052AlaSer: 2.052 ± 0.433
4.01AlaThr: 4.01 ± 0.666
5.689AlaVal: 5.689 ± 0.877
1.679AlaTrp: 1.679 ± 0.464
1.772AlaTyr: 1.772 ± 0.377
0.0AlaXaa: 0.0 ± 0.0
Cys
0.28CysAla: 0.28 ± 0.134
0.187CysCys: 0.187 ± 0.122
0.373CysAsp: 0.373 ± 0.207
0.56CysGlu: 0.56 ± 0.191
0.28CysPhe: 0.28 ± 0.167
0.466CysGly: 0.466 ± 0.282
0.093CysHis: 0.093 ± 0.088
0.746CysIle: 0.746 ± 0.387
0.746CysLys: 0.746 ± 0.288
0.373CysLeu: 0.373 ± 0.16
0.093CysMet: 0.093 ± 0.097
0.187CysAsn: 0.187 ± 0.164
0.187CysPro: 0.187 ± 0.136
0.373CysGln: 0.373 ± 0.173
0.373CysArg: 0.373 ± 0.172
0.373CysSer: 0.373 ± 0.179
0.093CysThr: 0.093 ± 0.083
0.093CysVal: 0.093 ± 0.099
0.093CysTrp: 0.093 ± 0.082
0.56CysTyr: 0.56 ± 0.214
0.0CysXaa: 0.0 ± 0.0
Asp
4.29AspAla: 4.29 ± 0.673
0.839AspCys: 0.839 ± 0.274
3.451AspAsp: 3.451 ± 0.645
4.477AspGlu: 4.477 ± 1.032
3.264AspPhe: 3.264 ± 0.59
4.85AspGly: 4.85 ± 0.534
0.373AspHis: 0.373 ± 0.207
5.13AspIle: 5.13 ± 0.665
4.943AspLys: 4.943 ± 0.737
5.596AspLeu: 5.596 ± 0.726
1.959AspMet: 1.959 ± 0.401
2.705AspAsn: 2.705 ± 0.559
2.145AspPro: 2.145 ± 0.548
1.586AspGln: 1.586 ± 0.319
2.332AspArg: 2.332 ± 0.462
3.264AspSer: 3.264 ± 0.477
4.29AspThr: 4.29 ± 0.415
3.637AspVal: 3.637 ± 0.513
1.865AspTrp: 1.865 ± 0.458
3.544AspTyr: 3.544 ± 0.635
0.0AspXaa: 0.0 ± 0.0
Glu
5.876GluAla: 5.876 ± 0.76
0.373GluCys: 0.373 ± 0.15
3.917GluAsp: 3.917 ± 0.859
6.715GluGlu: 6.715 ± 1.087
3.824GluPhe: 3.824 ± 0.68
2.798GluGly: 2.798 ± 0.484
1.306GluHis: 1.306 ± 0.298
6.062GluIle: 6.062 ± 0.626
7.275GluLys: 7.275 ± 1.14
9.233GluLeu: 9.233 ± 1.093
2.425GluMet: 2.425 ± 0.651
4.943GluAsn: 4.943 ± 0.642
1.959GluPro: 1.959 ± 0.452
3.544GluGln: 3.544 ± 0.595
5.503GluArg: 5.503 ± 0.658
4.663GluSer: 4.663 ± 0.711
3.824GluThr: 3.824 ± 0.698
5.503GluVal: 5.503 ± 0.733
0.746GluTrp: 0.746 ± 0.22
2.705GluTyr: 2.705 ± 0.52
0.0GluXaa: 0.0 ± 0.0
Phe
2.425PheAla: 2.425 ± 0.595
0.373PheCys: 0.373 ± 0.174
5.036PheAsp: 5.036 ± 0.557
3.824PheGlu: 3.824 ± 0.741
1.772PhePhe: 1.772 ± 0.44
2.145PheGly: 2.145 ± 0.731
0.373PheHis: 0.373 ± 0.19
1.772PheIle: 1.772 ± 0.502
3.451PheLys: 3.451 ± 0.512
2.425PheLeu: 2.425 ± 0.438
1.119PheMet: 1.119 ± 0.362
2.705PheAsn: 2.705 ± 0.523
0.746PhePro: 0.746 ± 0.263
1.865PheGln: 1.865 ± 0.386
1.119PheArg: 1.119 ± 0.259
3.358PheSer: 3.358 ± 0.688
2.611PheThr: 2.611 ± 0.435
1.399PheVal: 1.399 ± 0.332
0.56PheTrp: 0.56 ± 0.247
2.145PheTyr: 2.145 ± 0.416
0.0PheXaa: 0.0 ± 0.0
Gly
3.078GlyAla: 3.078 ± 0.563
0.0GlyCys: 0.0 ± 0.0
3.824GlyAsp: 3.824 ± 0.552
5.223GlyGlu: 5.223 ± 0.698
2.518GlyPhe: 2.518 ± 0.687
5.036GlyGly: 5.036 ± 1.313
0.746GlyHis: 0.746 ± 0.252
3.358GlyIle: 3.358 ± 0.615
5.316GlyLys: 5.316 ± 0.68
5.409GlyLeu: 5.409 ± 1.226
1.959GlyMet: 1.959 ± 0.406
3.824GlyAsn: 3.824 ± 0.533
0.746GlyPro: 0.746 ± 0.285
3.637GlyGln: 3.637 ± 0.466
3.358GlyArg: 3.358 ± 0.564
4.104GlySer: 4.104 ± 0.796
2.798GlyThr: 2.798 ± 0.483
5.036GlyVal: 5.036 ± 0.742
0.746GlyTrp: 0.746 ± 0.248
2.985GlyTyr: 2.985 ± 0.453
0.0GlyXaa: 0.0 ± 0.0
His
0.746HisAla: 0.746 ± 0.305
0.093HisCys: 0.093 ± 0.1
0.653HisAsp: 0.653 ± 0.317
1.026HisGlu: 1.026 ± 0.271
0.746HisPhe: 0.746 ± 0.217
1.026HisGly: 1.026 ± 0.344
0.093HisHis: 0.093 ± 0.091
0.373HisIle: 0.373 ± 0.228
0.653HisLys: 0.653 ± 0.233
1.026HisLeu: 1.026 ± 0.267
0.28HisMet: 0.28 ± 0.17
1.026HisAsn: 1.026 ± 0.274
0.746HisPro: 0.746 ± 0.221
0.653HisGln: 0.653 ± 0.249
0.746HisArg: 0.746 ± 0.296
0.933HisSer: 0.933 ± 0.251
0.653HisThr: 0.653 ± 0.251
0.933HisVal: 0.933 ± 0.284
0.187HisTrp: 0.187 ± 0.122
0.746HisTyr: 0.746 ± 0.267
0.0HisXaa: 0.0 ± 0.0
Ile
5.689IleAla: 5.689 ± 0.711
0.373IleCys: 0.373 ± 0.13
3.731IleAsp: 3.731 ± 0.74
6.342IleGlu: 6.342 ± 0.736
2.985IlePhe: 2.985 ± 0.559
3.917IleGly: 3.917 ± 0.814
0.466IleHis: 0.466 ± 0.195
3.264IleIle: 3.264 ± 0.538
6.902IleLys: 6.902 ± 0.758
4.01IleLeu: 4.01 ± 0.724
1.212IleMet: 1.212 ± 0.352
3.917IleAsn: 3.917 ± 0.68
1.399IlePro: 1.399 ± 0.397
2.705IleGln: 2.705 ± 0.41
2.705IleArg: 2.705 ± 0.449
4.757IleSer: 4.757 ± 0.628
4.104IleThr: 4.104 ± 0.709
3.264IleVal: 3.264 ± 0.571
0.28IleTrp: 0.28 ± 0.154
2.052IleTyr: 2.052 ± 0.557
0.0IleXaa: 0.0 ± 0.0
Lys
5.596LysAla: 5.596 ± 0.763
0.466LysCys: 0.466 ± 0.185
6.062LysAsp: 6.062 ± 0.554
7.648LysGlu: 7.648 ± 0.848
2.518LysPhe: 2.518 ± 0.471
4.477LysGly: 4.477 ± 0.586
1.119LysHis: 1.119 ± 0.281
6.435LysIle: 6.435 ± 0.936
7.555LysLys: 7.555 ± 1.243
6.529LysLeu: 6.529 ± 0.875
2.798LysMet: 2.798 ± 0.461
5.316LysAsn: 5.316 ± 0.618
2.518LysPro: 2.518 ± 0.69
3.637LysGln: 3.637 ± 0.705
4.197LysArg: 4.197 ± 0.443
3.731LysSer: 3.731 ± 0.463
4.29LysThr: 4.29 ± 0.499
6.435LysVal: 6.435 ± 0.667
1.026LysTrp: 1.026 ± 0.319
3.917LysTyr: 3.917 ± 0.626
0.0LysXaa: 0.0 ± 0.0
Leu
6.529LeuAla: 6.529 ± 0.977
0.653LeuCys: 0.653 ± 0.284
5.969LeuAsp: 5.969 ± 0.769
7.648LeuGlu: 7.648 ± 0.97
2.705LeuPhe: 2.705 ± 0.5
5.969LeuGly: 5.969 ± 1.428
1.306LeuHis: 1.306 ± 0.323
4.29LeuIle: 4.29 ± 0.538
6.715LeuLys: 6.715 ± 0.714
7.181LeuLeu: 7.181 ± 1.026
2.052LeuMet: 2.052 ± 0.4
3.264LeuAsn: 3.264 ± 0.424
2.425LeuPro: 2.425 ± 0.593
2.985LeuGln: 2.985 ± 0.521
4.384LeuArg: 4.384 ± 0.683
5.13LeuSer: 5.13 ± 0.946
4.57LeuThr: 4.57 ± 0.519
3.264LeuVal: 3.264 ± 0.456
0.746LeuTrp: 0.746 ± 0.26
2.518LeuTyr: 2.518 ± 0.437
0.0LeuXaa: 0.0 ± 0.0
Met
1.959MetAla: 1.959 ± 0.447
0.093MetCys: 0.093 ± 0.111
1.679MetAsp: 1.679 ± 0.28
1.959MetGlu: 1.959 ± 0.483
1.026MetPhe: 1.026 ± 0.272
1.586MetGly: 1.586 ± 0.425
0.466MetHis: 0.466 ± 0.272
1.679MetIle: 1.679 ± 0.453
2.891MetLys: 2.891 ± 0.606
1.865MetLeu: 1.865 ± 0.359
0.466MetMet: 0.466 ± 0.22
1.492MetAsn: 1.492 ± 0.366
0.653MetPro: 0.653 ± 0.288
1.119MetGln: 1.119 ± 0.32
0.933MetArg: 0.933 ± 0.273
1.586MetSer: 1.586 ± 0.412
2.052MetThr: 2.052 ± 0.437
1.306MetVal: 1.306 ± 0.308
0.28MetTrp: 0.28 ± 0.159
0.746MetTyr: 0.746 ± 0.214
0.0MetXaa: 0.0 ± 0.0
Asn
5.036AsnAla: 5.036 ± 0.841
0.373AsnCys: 0.373 ± 0.155
2.891AsnAsp: 2.891 ± 0.419
3.917AsnGlu: 3.917 ± 0.724
1.865AsnPhe: 1.865 ± 0.395
3.917AsnGly: 3.917 ± 0.62
1.212AsnHis: 1.212 ± 0.379
3.637AsnIle: 3.637 ± 0.582
4.104AsnLys: 4.104 ± 0.54
3.917AsnLeu: 3.917 ± 0.639
1.026AsnMet: 1.026 ± 0.307
2.332AsnAsn: 2.332 ± 0.475
1.772AsnPro: 1.772 ± 0.393
2.891AsnGln: 2.891 ± 0.593
2.705AsnArg: 2.705 ± 0.62
3.078AsnSer: 3.078 ± 0.674
3.171AsnThr: 3.171 ± 0.51
3.171AsnVal: 3.171 ± 0.465
0.839AsnTrp: 0.839 ± 0.207
1.865AsnTyr: 1.865 ± 0.43
0.0AsnXaa: 0.0 ± 0.0
Pro
2.332ProAla: 2.332 ± 0.443
0.0ProCys: 0.0 ± 0.0
2.145ProAsp: 2.145 ± 0.513
3.451ProGlu: 3.451 ± 0.636
1.399ProPhe: 1.399 ± 0.493
0.933ProGly: 0.933 ± 0.245
0.373ProHis: 0.373 ± 0.164
1.772ProIle: 1.772 ± 0.495
2.518ProLys: 2.518 ± 0.395
1.306ProLeu: 1.306 ± 0.352
0.373ProMet: 0.373 ± 0.178
0.933ProAsn: 0.933 ± 0.376
1.026ProPro: 1.026 ± 0.328
1.306ProGln: 1.306 ± 0.472
1.212ProArg: 1.212 ± 0.311
1.026ProSer: 1.026 ± 0.416
0.839ProThr: 0.839 ± 0.264
1.865ProVal: 1.865 ± 0.348
0.56ProTrp: 0.56 ± 0.214
1.212ProTyr: 1.212 ± 0.392
0.0ProXaa: 0.0 ± 0.0
Gln
2.891GlnAla: 2.891 ± 0.472
0.466GlnCys: 0.466 ± 0.163
1.679GlnAsp: 1.679 ± 0.341
4.104GlnGlu: 4.104 ± 0.761
1.212GlnPhe: 1.212 ± 0.329
2.611GlnGly: 2.611 ± 0.552
0.28GlnHis: 0.28 ± 0.17
3.264GlnIle: 3.264 ± 0.614
3.264GlnLys: 3.264 ± 0.481
3.078GlnLeu: 3.078 ± 0.392
0.746GlnMet: 0.746 ± 0.223
2.052GlnAsn: 2.052 ± 0.489
1.026GlnPro: 1.026 ± 0.303
1.772GlnGln: 1.772 ± 0.415
2.332GlnArg: 2.332 ± 0.463
2.985GlnSer: 2.985 ± 0.447
2.332GlnThr: 2.332 ± 0.417
4.197GlnVal: 4.197 ± 0.647
0.56GlnTrp: 0.56 ± 0.201
0.839GlnTyr: 0.839 ± 0.267
0.0GlnXaa: 0.0 ± 0.0
Arg
3.171ArgAla: 3.171 ± 0.502
0.373ArgCys: 0.373 ± 0.164
2.518ArgAsp: 2.518 ± 0.529
3.358ArgGlu: 3.358 ± 0.644
2.145ArgPhe: 2.145 ± 0.601
1.865ArgGly: 1.865 ± 0.533
0.653ArgHis: 0.653 ± 0.221
3.264ArgIle: 3.264 ± 0.466
4.757ArgLys: 4.757 ± 0.768
5.036ArgLeu: 5.036 ± 0.646
2.052ArgMet: 2.052 ± 0.394
2.611ArgAsn: 2.611 ± 0.633
0.839ArgPro: 0.839 ± 0.247
2.518ArgGln: 2.518 ± 0.515
2.145ArgArg: 2.145 ± 0.498
2.145ArgSer: 2.145 ± 0.415
2.611ArgThr: 2.611 ± 0.616
2.891ArgVal: 2.891 ± 0.451
0.373ArgTrp: 0.373 ± 0.161
1.586ArgTyr: 1.586 ± 0.363
0.0ArgXaa: 0.0 ± 0.0
Ser
4.29SerAla: 4.29 ± 0.987
0.093SerCys: 0.093 ± 0.073
3.917SerAsp: 3.917 ± 0.737
3.731SerGlu: 3.731 ± 0.777
1.865SerPhe: 1.865 ± 0.425
5.13SerGly: 5.13 ± 0.738
1.119SerHis: 1.119 ± 0.33
3.544SerIle: 3.544 ± 0.809
4.663SerLys: 4.663 ± 0.594
4.384SerLeu: 4.384 ± 0.728
1.586SerMet: 1.586 ± 0.436
3.171SerAsn: 3.171 ± 0.601
1.492SerPro: 1.492 ± 0.253
1.865SerGln: 1.865 ± 0.312
3.264SerArg: 3.264 ± 0.623
2.705SerSer: 2.705 ± 0.577
3.917SerThr: 3.917 ± 0.413
2.705SerVal: 2.705 ± 0.574
0.933SerTrp: 0.933 ± 0.476
2.332SerTyr: 2.332 ± 0.557
0.0SerXaa: 0.0 ± 0.0
Thr
4.663ThrAla: 4.663 ± 0.685
0.187ThrCys: 0.187 ± 0.147
4.104ThrAsp: 4.104 ± 0.551
4.01ThrGlu: 4.01 ± 0.538
3.078ThrPhe: 3.078 ± 0.738
4.01ThrGly: 4.01 ± 0.649
0.839ThrHis: 0.839 ± 0.34
4.57ThrIle: 4.57 ± 0.746
3.824ThrLys: 3.824 ± 0.632
3.917ThrLeu: 3.917 ± 0.676
0.933ThrMet: 0.933 ± 0.294
2.891ThrAsn: 2.891 ± 0.391
1.399ThrPro: 1.399 ± 0.379
2.611ThrGln: 2.611 ± 0.451
1.399ThrArg: 1.399 ± 0.331
3.731ThrSer: 3.731 ± 0.611
5.036ThrThr: 5.036 ± 0.795
4.477ThrVal: 4.477 ± 0.78
0.746ThrTrp: 0.746 ± 0.263
2.425ThrTyr: 2.425 ± 0.548
0.0ThrXaa: 0.0 ± 0.0
Val
5.316ValAla: 5.316 ± 0.698
0.373ValCys: 0.373 ± 0.196
3.078ValAsp: 3.078 ± 0.518
4.943ValGlu: 4.943 ± 0.776
2.611ValPhe: 2.611 ± 0.487
5.13ValGly: 5.13 ± 0.822
0.933ValHis: 0.933 ± 0.371
2.891ValIle: 2.891 ± 0.506
6.062ValLys: 6.062 ± 0.698
4.477ValLeu: 4.477 ± 0.576
1.212ValMet: 1.212 ± 0.325
4.29ValAsn: 4.29 ± 0.758
2.145ValPro: 2.145 ± 0.332
1.306ValGln: 1.306 ± 0.416
2.425ValArg: 2.425 ± 0.37
4.29ValSer: 4.29 ± 0.621
4.943ValThr: 4.943 ± 0.673
4.663ValVal: 4.663 ± 0.831
0.373ValTrp: 0.373 ± 0.136
3.358ValTyr: 3.358 ± 0.707
0.0ValXaa: 0.0 ± 0.0
Trp
1.119TrpAla: 1.119 ± 0.327
0.187TrpCys: 0.187 ± 0.117
0.839TrpAsp: 0.839 ± 0.344
0.653TrpGlu: 0.653 ± 0.251
0.933TrpPhe: 0.933 ± 0.512
0.746TrpGly: 0.746 ± 0.248
0.093TrpHis: 0.093 ± 0.103
0.746TrpIle: 0.746 ± 0.276
1.306TrpLys: 1.306 ± 0.395
0.56TrpLeu: 0.56 ± 0.277
0.28TrpMet: 0.28 ± 0.155
1.212TrpAsn: 1.212 ± 0.37
0.187TrpPro: 0.187 ± 0.114
0.56TrpGln: 0.56 ± 0.306
0.746TrpArg: 0.746 ± 0.289
0.466TrpSer: 0.466 ± 0.167
0.746TrpThr: 0.746 ± 0.309
1.212TrpVal: 1.212 ± 0.32
0.093TrpTrp: 0.093 ± 0.073
0.187TrpTyr: 0.187 ± 0.133
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.399TyrAla: 1.399 ± 0.321
0.839TyrCys: 0.839 ± 0.264
2.798TyrAsp: 2.798 ± 0.426
3.358TyrGlu: 3.358 ± 0.645
1.399TyrPhe: 1.399 ± 0.372
1.959TyrGly: 1.959 ± 0.393
1.026TyrHis: 1.026 ± 0.268
2.611TyrIle: 2.611 ± 0.476
3.731TyrLys: 3.731 ± 0.689
2.985TyrLeu: 2.985 ± 0.503
0.653TyrMet: 0.653 ± 0.269
1.492TyrAsn: 1.492 ± 0.434
1.399TyrPro: 1.399 ± 0.339
1.959TyrGln: 1.959 ± 0.44
2.332TyrArg: 2.332 ± 0.62
2.332TyrSer: 2.332 ± 0.496
1.959TyrThr: 1.959 ± 0.394
3.078TyrVal: 3.078 ± 0.673
0.187TyrTrp: 0.187 ± 0.121
1.586TyrTyr: 1.586 ± 0.425
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 57 proteins (10723 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski