Amino acid dipepetide frequency for Plasmodium ovale wallikeri

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	1.768AlaAla: 1.768 ± 0.04	0.704AlaCys: 0.704 ± 0.013	1.858AlaAsp: 1.858 ± 0.027	2.583AlaGlu: 2.583 ± 0.049	1.36AlaPhe: 1.36 ± 0.022	1.592AlaGly: 1.592 ± 0.026	1.074AlaHis: 1.074 ± 0.018	2.06AlaIle: 2.06 ± 0.027	3.13AlaLys: 3.13 ± 0.047	2.757AlaLeu: 2.757 ± 0.028	0.669AlaMet: 0.669 ± 0.014	2.852AlaAsn: 2.852 ± 0.037	1.128AlaPro: 1.128 ± 0.021	1.228AlaGln: 1.228 ± 0.018	1.304AlaArg: 1.304 ± 0.021	2.884AlaSer: 2.884 ± 0.034	1.879AlaThr: 1.879 ± 0.025	1.682AlaVal: 1.682 ± 0.027	0.201AlaTrp: 0.201 ± 0.007	1.654AlaTyr: 1.654 ± 0.02	0.0AlaXaa: 0.0 ± 0.0
Cys	0.976CysAla: 0.976 ± 0.019	0.449CysCys: 0.449 ± 0.01	1.28CysAsp: 1.28 ± 0.021	1.593CysGlu: 1.593 ± 0.021	0.868CysPhe: 0.868 ± 0.016	0.939CysGly: 0.939 ± 0.016	0.436CysHis: 0.436 ± 0.01	1.68CysIle: 1.68 ± 0.022	2.143CysLys: 2.143 ± 0.023	1.62CysLeu: 1.62 ± 0.02	0.426CysMet: 0.426 ± 0.009	1.808CysAsn: 1.808 ± 0.023	0.662CysPro: 0.662 ± 0.016	0.436CysGln: 0.436 ± 0.01	0.869CysArg: 0.869 ± 0.015	1.926CysSer: 1.926 ± 0.024	1.361CysThr: 1.361 ± 0.019	1.106CysVal: 1.106 ± 0.018	0.088CysTrp: 0.088 ± 0.004	0.855CysTyr: 0.855 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	2.331AspAla: 2.331 ± 0.031	0.915AspCys: 0.915 ± 0.018	4.345AspAsp: 4.345 ± 0.058	5.316AspGlu: 5.316 ± 0.046	2.378AspPhe: 2.378 ± 0.026	2.859AspGly: 2.859 ± 0.045	1.116AspHis: 1.116 ± 0.018	5.178AspIle: 5.178 ± 0.039	4.93AspLys: 4.93 ± 0.04	3.84AspLeu: 3.84 ± 0.036	1.415AspMet: 1.415 ± 0.018	4.765AspAsn: 4.765 ± 0.042	1.273AspPro: 1.273 ± 0.02	1.211AspGln: 1.211 ± 0.02	1.967AspArg: 1.967 ± 0.036	4.041AspSer: 4.041 ± 0.037	2.897AspThr: 2.897 ± 0.029	3.471AspVal: 3.471 ± 0.037	0.297AspTrp: 0.297 ± 0.009	2.613AspTyr: 2.613 ± 0.027	0.0AspXaa: 0.0 ± 0.0
Glu	2.651GluAla: 2.651 ± 0.045	1.381GluCys: 1.381 ± 0.021	4.908GluAsp: 4.908 ± 0.05	9.595GluGlu: 9.595 ± 0.105	2.243GluPhe: 2.243 ± 0.025	3.967GluGly: 3.967 ± 0.045	1.796GluHis: 1.796 ± 0.026	5.004GluIle: 5.004 ± 0.044	10.952GluLys: 10.952 ± 0.086	5.113GluLeu: 5.113 ± 0.053	1.735GluMet: 1.735 ± 0.024	7.907GluAsn: 7.907 ± 0.059	1.198GluPro: 1.198 ± 0.02	2.473GluGln: 2.473 ± 0.035	3.594GluArg: 3.594 ± 0.044	4.438GluSer: 4.438 ± 0.045	3.057GluThr: 3.057 ± 0.031	3.198GluVal: 3.198 ± 0.038	0.561GluTrp: 0.561 ± 0.014	3.109GluTyr: 3.109 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	1.351PheAla: 1.351 ± 0.02	1.173PheCys: 1.173 ± 0.018	2.407PheAsp: 2.407 ± 0.027	2.493PheGlu: 2.493 ± 0.03	3.369PhePhe: 3.369 ± 0.045	1.704PheGly: 1.704 ± 0.026	1.177PheHis: 1.177 ± 0.016	3.184PheIle: 3.184 ± 0.031	3.396PheLys: 3.396 ± 0.032	5.081PheLeu: 5.081 ± 0.049	0.868PheMet: 0.868 ± 0.016	3.373PheAsn: 3.373 ± 0.035	1.584PhePro: 1.584 ± 0.024	1.213PheGln: 1.213 ± 0.018	1.508PheArg: 1.508 ± 0.02	3.966PheSer: 3.966 ± 0.032	2.165PheThr: 2.165 ± 0.025	2.205PheVal: 2.205 ± 0.025	0.289PheTrp: 0.289 ± 0.009	2.667PheTyr: 2.667 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	1.845GlyAla: 1.845 ± 0.028	0.851GlyCys: 0.851 ± 0.017	3.306GlyAsp: 3.306 ± 0.04	4.991GlyGlu: 4.991 ± 0.062	1.33GlyPhe: 1.33 ± 0.016	4.196GlyGly: 4.196 ± 0.069	1.029GlyHis: 1.029 ± 0.017	3.18GlyIle: 3.18 ± 0.033	5.468GlyLys: 5.468 ± 0.045	2.317GlyLeu: 2.317 ± 0.029	0.95GlyMet: 0.95 ± 0.018	4.665GlyAsn: 4.665 ± 0.067	0.777GlyPro: 0.777 ± 0.017	1.123GlyGln: 1.123 ± 0.027	2.397GlyArg: 2.397 ± 0.037	4.441GlySer: 4.441 ± 0.062	2.441GlyThr: 2.441 ± 0.026	2.429GlyVal: 2.429 ± 0.036	0.235GlyTrp: 0.235 ± 0.007	1.765GlyTyr: 1.765 ± 0.026	0.0GlyXaa: 0.0 ± 0.0
His	0.996HisAla: 0.996 ± 0.015	0.481HisCys: 0.481 ± 0.011	1.31HisAsp: 1.31 ± 0.019	1.506HisGlu: 1.506 ± 0.023	1.508HisPhe: 1.508 ± 0.022	1.231HisGly: 1.231 ± 0.023	0.639HisHis: 0.639 ± 0.016	2.152HisIle: 2.152 ± 0.025	1.874HisLys: 1.874 ± 0.026	2.207HisLeu: 2.207 ± 0.028	0.712HisMet: 0.712 ± 0.013	1.96HisAsn: 1.96 ± 0.025	0.786HisPro: 0.786 ± 0.017	0.546HisGln: 0.546 ± 0.013	0.969HisArg: 0.969 ± 0.017	1.987HisSer: 1.987 ± 0.023	1.321HisThr: 1.321 ± 0.02	1.489HisVal: 1.489 ± 0.02	0.139HisTrp: 0.139 ± 0.007	1.046HisTyr: 1.046 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	2.122IleAla: 2.122 ± 0.026	1.856IleCys: 1.856 ± 0.025	3.911IleAsp: 3.911 ± 0.031	4.565IleGlu: 4.565 ± 0.048	4.017IlePhe: 4.017 ± 0.035	2.807IleGly: 2.807 ± 0.031	1.937IleHis: 1.937 ± 0.019	5.315IleIle: 5.315 ± 0.053	6.827IleLys: 6.827 ± 0.05	6.804IleLeu: 6.804 ± 0.052	1.269IleMet: 1.269 ± 0.017	6.563IleAsn: 6.563 ± 0.045	2.464IlePro: 2.464 ± 0.029	2.063IleGln: 2.063 ± 0.027	2.643IleArg: 2.643 ± 0.03	5.844IleSer: 5.844 ± 0.037	3.223IleThr: 3.223 ± 0.033	2.977IleVal: 2.977 ± 0.032	0.497IleTrp: 0.497 ± 0.011	4.018IleTyr: 4.018 ± 0.041	0.0IleXaa: 0.0 ± 0.0
Lys	2.606LysAla: 2.606 ± 0.046	2.288LysCys: 2.288 ± 0.026	5.105LysAsp: 5.105 ± 0.044	9.237LysGlu: 9.237 ± 0.089	3.333LysPhe: 3.333 ± 0.033	4.995LysGly: 4.995 ± 0.048	2.164LysHis: 2.164 ± 0.024	7.742LysIle: 7.742 ± 0.053	15.84LysLys: 15.84 ± 0.119	7.043LysLeu: 7.043 ± 0.048	2.483LysMet: 2.483 ± 0.025	10.566LysAsn: 10.566 ± 0.066	1.64LysPro: 1.64 ± 0.025	2.613LysGln: 2.613 ± 0.031	5.323LysArg: 5.323 ± 0.046	6.171LysSer: 6.171 ± 0.045	4.09LysThr: 4.09 ± 0.037	3.876LysVal: 3.876 ± 0.035	0.866LysTrp: 0.866 ± 0.019	5.077LysTyr: 5.077 ± 0.037	0.0LysXaa: 0.0 ± 0.0
Leu	2.203LeuAla: 2.203 ± 0.027	2.002LeuCys: 2.002 ± 0.024	3.453LeuAsp: 3.453 ± 0.035	4.694LeuGlu: 4.694 ± 0.044	4.475LeuPhe: 4.475 ± 0.041	3.112LeuGly: 3.112 ± 0.035	2.399LeuHis: 2.399 ± 0.025	4.979LeuIle: 4.979 ± 0.048	8.085LeuLys: 8.085 ± 0.054	7.636LeuLeu: 7.636 ± 0.063	1.412LeuMet: 1.412 ± 0.016	6.776LeuAsn: 6.776 ± 0.045	2.769LeuPro: 2.769 ± 0.035	2.638LeuGln: 2.638 ± 0.027	3.464LeuArg: 3.464 ± 0.031	6.404LeuSer: 6.404 ± 0.037	3.375LeuThr: 3.375 ± 0.031	2.909LeuVal: 2.909 ± 0.028	0.542LeuTrp: 0.542 ± 0.011	4.581LeuTyr: 4.581 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	0.637MetAla: 0.637 ± 0.012	0.532MetCys: 0.532 ± 0.01	1.274MetAsp: 1.274 ± 0.017	1.754MetGlu: 1.754 ± 0.023	0.869MetPhe: 0.869 ± 0.014	1.112MetGly: 1.112 ± 0.02	0.755MetHis: 0.755 ± 0.014	1.068MetIle: 1.068 ± 0.017	2.223MetLys: 2.223 ± 0.024	1.606MetLeu: 1.606 ± 0.023	0.45MetMet: 0.45 ± 0.01	2.227MetAsn: 2.227 ± 0.033	0.541MetPro: 0.541 ± 0.013	0.785MetGln: 0.785 ± 0.013	0.907MetArg: 0.907 ± 0.017	1.586MetSer: 1.586 ± 0.022	0.801MetThr: 0.801 ± 0.017	0.84MetVal: 0.84 ± 0.017	0.149MetTrp: 0.149 ± 0.006	1.145MetTyr: 1.145 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.315AsnAla: 3.315 ± 0.043	1.849AsnCys: 1.849 ± 0.025	5.534AsnAsp: 5.534 ± 0.047	7.204AsnGlu: 7.204 ± 0.049	4.414AsnPhe: 4.414 ± 0.039	4.616AsnGly: 4.616 ± 0.061	1.645AsnHis: 1.645 ± 0.019	8.079AsnIle: 8.079 ± 0.058	7.825AsnLys: 7.825 ± 0.058	6.344AsnLeu: 6.344 ± 0.04	2.357AsnMet: 2.357 ± 0.031	8.573AsnAsn: 8.573 ± 0.125	1.926AsnPro: 1.926 ± 0.029	1.746AsnGln: 1.746 ± 0.027	3.255AsnArg: 3.255 ± 0.039	7.258AsnSer: 7.258 ± 0.065	4.258AsnThr: 4.258 ± 0.036	5.4AsnVal: 5.4 ± 0.044	0.461AsnTrp: 0.461 ± 0.01	4.804AsnTyr: 4.804 ± 0.041	0.0AsnXaa: 0.0 ± 0.0
Pro	0.878ProAla: 0.878 ± 0.019	0.611ProCys: 0.611 ± 0.013	1.183ProAsp: 1.183 ± 0.021	1.468ProGlu: 1.468 ± 0.025	1.76ProPhe: 1.76 ± 0.025	1.074ProGly: 1.074 ± 0.026	0.808ProHis: 0.808 ± 0.017	1.798ProIle: 1.798 ± 0.024	1.824ProLys: 1.824 ± 0.024	2.644ProLeu: 2.644 ± 0.03	0.504ProMet: 0.504 ± 0.013	2.032ProAsn: 2.032 ± 0.031	1.467ProPro: 1.467 ± 0.04	0.93ProGln: 0.93 ± 0.019	0.973ProArg: 0.973 ± 0.019	2.667ProSer: 2.667 ± 0.034	1.4ProThr: 1.4 ± 0.024	1.395ProVal: 1.395 ± 0.023	0.2ProTrp: 0.2 ± 0.007	1.225ProTyr: 1.225 ± 0.02	0.0ProXaa: 0.0 ± 0.0
Gln	0.863GlnAla: 0.863 ± 0.019	0.542GlnCys: 0.542 ± 0.012	1.262GlnAsp: 1.262 ± 0.022	2.051GlnGlu: 2.051 ± 0.029	1.087GlnPhe: 1.087 ± 0.016	1.347GlnGly: 1.347 ± 0.022	0.712GlnHis: 0.712 ± 0.016	1.918GlnIle: 1.918 ± 0.024	3.122GlnLys: 3.122 ± 0.03	2.088GlnLeu: 2.088 ± 0.024	0.746GlnMet: 0.746 ± 0.015	2.849GlnAsn: 2.849 ± 0.031	0.707GlnPro: 0.707 ± 0.018	1.043GlnGln: 1.043 ± 0.03	1.31GlnArg: 1.31 ± 0.02	1.945GlnSer: 1.945 ± 0.027	1.285GlnThr: 1.285 ± 0.02	1.207GlnVal: 1.207 ± 0.025	0.246GlnTrp: 0.246 ± 0.008	1.174GlnTyr: 1.174 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	1.344ArgAla: 1.344 ± 0.022	0.954ArgCys: 0.954 ± 0.016	2.517ArgAsp: 2.517 ± 0.035	3.842ArgGlu: 3.842 ± 0.043	1.249ArgPhe: 1.249 ± 0.018	2.719ArgGly: 2.719 ± 0.041	0.927ArgHis: 0.927 ± 0.017	2.571ArgIle: 2.571 ± 0.026	5.309ArgLys: 5.309 ± 0.047	2.334ArgLeu: 2.334 ± 0.025	0.874ArgMet: 0.874 ± 0.014	4.046ArgAsn: 4.046 ± 0.04	0.666ArgPro: 0.666 ± 0.015	1.011ArgGln: 1.011 ± 0.017	2.746ArgArg: 2.746 ± 0.047	3.216ArgSer: 3.216 ± 0.044	1.818ArgThr: 1.818 ± 0.023	1.725ArgVal: 1.725 ± 0.022	0.292ArgTrp: 0.292 ± 0.009	1.602ArgTyr: 1.602 ± 0.023	0.0ArgXaa: 0.0 ± 0.0
Ser	3.003SerAla: 3.003 ± 0.032	1.554SerCys: 1.554 ± 0.02	4.59SerAsp: 4.59 ± 0.037	5.267SerGlu: 5.267 ± 0.05	3.768SerPhe: 3.768 ± 0.034	4.592SerGly: 4.592 ± 0.06	1.995SerHis: 1.995 ± 0.027	5.141SerIle: 5.141 ± 0.034	6.413SerLys: 6.413 ± 0.043	6.174SerLeu: 6.174 ± 0.042	1.484SerMet: 1.484 ± 0.017	6.717SerAsn: 6.717 ± 0.065	2.482SerPro: 2.482 ± 0.034	2.119SerGln: 2.119 ± 0.029	3.031SerArg: 3.031 ± 0.039	8.299SerSer: 8.299 ± 0.088	4.203SerThr: 4.203 ± 0.037	3.789SerVal: 3.789 ± 0.033	0.447SerTrp: 0.447 ± 0.01	3.636SerTyr: 3.636 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	1.808ThrAla: 1.808 ± 0.03	1.193ThrCys: 1.193 ± 0.021	2.391ThrAsp: 2.391 ± 0.027	3.004ThrGlu: 3.004 ± 0.031	2.396ThrPhe: 2.396 ± 0.027	2.201ThrGly: 2.201 ± 0.033	1.465ThrHis: 1.465 ± 0.021	2.945ThrIle: 2.945 ± 0.026	3.989ThrLys: 3.989 ± 0.033	3.812ThrLeu: 3.812 ± 0.027	0.831ThrMet: 0.831 ± 0.014	4.054ThrAsn: 4.054 ± 0.035	1.989ThrPro: 1.989 ± 0.028	1.491ThrGln: 1.491 ± 0.02	1.639ThrArg: 1.639 ± 0.022	4.19ThrSer: 4.19 ± 0.035	2.564ThrThr: 2.564 ± 0.035	2.276ThrVal: 2.276 ± 0.022	0.31ThrTrp: 0.31 ± 0.009	2.44ThrTyr: 2.44 ± 0.025	0.0ThrXaa: 0.0 ± 0.0
Val	1.766ValAla: 1.766 ± 0.026	1.075ValCys: 1.075 ± 0.014	2.81ValAsp: 2.81 ± 0.031	3.641ValGlu: 3.641 ± 0.042	1.847ValPhe: 1.847 ± 0.019	2.473ValGly: 2.473 ± 0.039	1.565ValHis: 1.565 ± 0.02	2.964ValIle: 2.964 ± 0.032	4.472ValLys: 4.472 ± 0.033	3.818ValLeu: 3.818 ± 0.034	0.808ValMet: 0.808 ± 0.015	4.043ValAsn: 4.043 ± 0.036	1.46ValPro: 1.46 ± 0.022	1.615ValGln: 1.615 ± 0.022	1.981ValArg: 1.981 ± 0.021	3.671ValSer: 3.671 ± 0.039	2.283ValThr: 2.283 ± 0.027	2.211ValVal: 2.211 ± 0.031	0.268ValTrp: 0.268 ± 0.008	2.155ValTyr: 2.155 ± 0.025	0.0ValXaa: 0.0 ± 0.0
Trp	0.174TrpAla: 0.174 ± 0.007	0.128TrpCys: 0.128 ± 0.005	0.38TrpAsp: 0.38 ± 0.01	0.51TrpGlu: 0.51 ± 0.012	0.283TrpPhe: 0.283 ± 0.009	0.37TrpGly: 0.37 ± 0.011	0.118TrpHis: 0.118 ± 0.006	0.584TrpIle: 0.584 ± 0.015	0.862TrpLys: 0.862 ± 0.017	0.655TrpLeu: 0.655 ± 0.014	0.168TrpMet: 0.168 ± 0.006	0.564TrpAsn: 0.564 ± 0.012	0.114TrpPro: 0.114 ± 0.006	0.142TrpGln: 0.142 ± 0.006	0.301TrpArg: 0.301 ± 0.009	0.379TrpSer: 0.379 ± 0.01	0.246TrpThr: 0.246 ± 0.009	0.342TrpVal: 0.342 ± 0.009	0.043TrpTrp: 0.043 ± 0.003	0.193TrpTyr: 0.193 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.728TyrAla: 1.728 ± 0.022	0.984TyrCys: 0.984 ± 0.02	3.332TyrAsp: 3.332 ± 0.031	3.566TyrGlu: 3.566 ± 0.032	2.619TyrPhe: 2.619 ± 0.029	1.83TyrGly: 1.83 ± 0.025	1.104TyrHis: 1.104 ± 0.016	4.182TyrIle: 4.182 ± 0.033	4.377TyrLys: 4.377 ± 0.031	4.014TyrLeu: 4.014 ± 0.038	1.1TyrMet: 1.1 ± 0.016	4.522TyrAsn: 4.522 ± 0.037	1.207TyrPro: 1.207 ± 0.019	1.078TyrGln: 1.078 ± 0.017	1.58TyrArg: 1.58 ± 0.022	3.391TyrSer: 3.391 ± 0.031	2.322TyrThr: 2.322 ± 0.024	2.397TyrVal: 2.397 ± 0.026	0.427TyrTrp: 0.427 ± 0.01	2.448TyrTyr: 2.448 ± 0.033	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.004XaaXaa: 0.004 ± 0.003

Statistics based on 8410 proteins (4382162 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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