Amino acid dipepetide frequency for Streptococcus satellite phage Javan761

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.962AlaAla: 0.962 ± 0.474
0.24AlaCys: 0.24 ± 0.26
4.567AlaAsp: 4.567 ± 1.107
3.846AlaGlu: 3.846 ± 0.752
3.365AlaPhe: 3.365 ± 0.821
2.163AlaGly: 2.163 ± 0.624
0.721AlaHis: 0.721 ± 0.455
5.048AlaIle: 5.048 ± 0.864
3.846AlaLys: 3.846 ± 0.82
6.25AlaLeu: 6.25 ± 1.159
2.885AlaMet: 2.885 ± 1.162
3.846AlaAsn: 3.846 ± 0.872
0.721AlaPro: 0.721 ± 0.415
2.644AlaGln: 2.644 ± 0.679
4.567AlaArg: 4.567 ± 0.85
1.683AlaSer: 1.683 ± 0.568
3.125AlaThr: 3.125 ± 0.743
3.365AlaVal: 3.365 ± 0.797
0.481AlaTrp: 0.481 ± 0.393
3.125AlaTyr: 3.125 ± 0.976
0.0AlaXaa: 0.0 ± 0.0
Cys
0.481CysAla: 0.481 ± 0.301
0.0CysCys: 0.0 ± 0.0
0.24CysAsp: 0.24 ± 0.268
0.24CysGlu: 0.24 ± 0.26
0.481CysPhe: 0.481 ± 0.301
0.24CysGly: 0.24 ± 0.222
0.481CysHis: 0.481 ± 0.249
0.721CysIle: 0.721 ± 0.477
0.24CysLys: 0.24 ± 0.202
1.442CysLeu: 1.442 ± 0.449
0.24CysMet: 0.24 ± 0.242
0.24CysAsn: 0.24 ± 0.211
0.24CysPro: 0.24 ± 0.202
0.24CysGln: 0.24 ± 0.275
0.24CysArg: 0.24 ± 0.202
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.24CysVal: 0.24 ± 0.283
0.0CysTrp: 0.0 ± 0.0
0.24CysTyr: 0.24 ± 0.283
0.0CysXaa: 0.0 ± 0.0
Asp
2.163AspAla: 2.163 ± 0.626
0.481AspCys: 0.481 ± 0.321
4.327AspAsp: 4.327 ± 0.844
4.808AspGlu: 4.808 ± 1.138
3.846AspPhe: 3.846 ± 0.808
2.644AspGly: 2.644 ± 0.6
0.0AspHis: 0.0 ± 0.0
6.25AspIle: 6.25 ± 0.864
5.288AspLys: 5.288 ± 0.877
7.212AspLeu: 7.212 ± 1.221
2.404AspMet: 2.404 ± 0.632
2.885AspAsn: 2.885 ± 0.717
1.202AspPro: 1.202 ± 0.594
0.721AspGln: 0.721 ± 0.471
2.644AspArg: 2.644 ± 0.74
2.163AspSer: 2.163 ± 0.569
2.644AspThr: 2.644 ± 0.776
0.962AspVal: 0.962 ± 0.519
0.0AspTrp: 0.0 ± 0.0
4.327AspTyr: 4.327 ± 0.887
0.0AspXaa: 0.0 ± 0.0
Glu
6.731GluAla: 6.731 ± 1.689
1.202GluCys: 1.202 ± 0.508
3.846GluAsp: 3.846 ± 0.95
6.731GluGlu: 6.731 ± 1.746
2.885GluPhe: 2.885 ± 0.885
2.885GluGly: 2.885 ± 0.78
1.202GluHis: 1.202 ± 0.586
11.058GluIle: 11.058 ± 1.436
8.413GluLys: 8.413 ± 1.554
10.817GluLeu: 10.817 ± 1.573
3.125GluMet: 3.125 ± 0.726
7.452GluAsn: 7.452 ± 1.373
1.442GluPro: 1.442 ± 0.805
3.846GluGln: 3.846 ± 0.854
4.327GluArg: 4.327 ± 1.062
5.048GluSer: 5.048 ± 1.351
4.087GluThr: 4.087 ± 0.99
4.567GluVal: 4.567 ± 1.129
0.481GluTrp: 0.481 ± 0.249
3.365GluTyr: 3.365 ± 0.698
0.0GluXaa: 0.0 ± 0.0
Phe
1.202PheAla: 1.202 ± 0.674
0.0PheCys: 0.0 ± 0.0
2.885PheAsp: 2.885 ± 0.748
3.365PheGlu: 3.365 ± 1.004
2.163PhePhe: 2.163 ± 0.826
1.683PheGly: 1.683 ± 0.655
1.202PheHis: 1.202 ± 0.418
3.365PheIle: 3.365 ± 0.892
5.288PheLys: 5.288 ± 1.27
4.087PheLeu: 4.087 ± 0.887
0.721PheMet: 0.721 ± 0.415
1.923PheAsn: 1.923 ± 0.556
0.481PhePro: 0.481 ± 0.301
2.885PheGln: 2.885 ± 0.542
2.163PheArg: 2.163 ± 0.543
3.365PheSer: 3.365 ± 0.728
1.202PheThr: 1.202 ± 0.462
0.721PheVal: 0.721 ± 0.338
0.481PheTrp: 0.481 ± 0.287
2.404PheTyr: 2.404 ± 0.73
0.0PheXaa: 0.0 ± 0.0
Gly
1.683GlyAla: 1.683 ± 0.572
0.24GlyCys: 0.24 ± 0.202
1.683GlyAsp: 1.683 ± 0.849
2.885GlyGlu: 2.885 ± 0.839
1.923GlyPhe: 1.923 ± 0.627
0.962GlyGly: 0.962 ± 0.499
0.721GlyHis: 0.721 ± 0.346
4.567GlyIle: 4.567 ± 0.758
4.567GlyLys: 4.567 ± 0.939
4.808GlyLeu: 4.808 ± 1.359
1.202GlyMet: 1.202 ± 0.529
2.404GlyAsn: 2.404 ± 0.607
0.24GlyPro: 0.24 ± 0.202
2.644GlyGln: 2.644 ± 0.569
2.163GlyArg: 2.163 ± 0.706
1.683GlySer: 1.683 ± 0.679
1.683GlyThr: 1.683 ± 0.568
3.846GlyVal: 3.846 ± 0.864
0.962GlyTrp: 0.962 ± 0.665
1.923GlyTyr: 1.923 ± 0.707
0.0GlyXaa: 0.0 ± 0.0
His
1.923HisAla: 1.923 ± 0.772
0.0HisCys: 0.0 ± 0.0
0.481HisAsp: 0.481 ± 0.341
1.202HisGlu: 1.202 ± 0.584
1.202HisPhe: 1.202 ± 0.54
0.962HisGly: 0.962 ± 0.444
0.24HisHis: 0.24 ± 0.202
0.481HisIle: 0.481 ± 0.323
1.202HisLys: 1.202 ± 0.6
1.202HisLeu: 1.202 ± 0.527
0.0HisMet: 0.0 ± 0.0
1.202HisAsn: 1.202 ± 0.521
0.481HisPro: 0.481 ± 0.35
0.721HisGln: 0.721 ± 0.443
1.683HisArg: 1.683 ± 0.577
0.962HisSer: 0.962 ± 0.39
0.481HisThr: 0.481 ± 0.404
0.481HisVal: 0.481 ± 0.301
0.0HisTrp: 0.0 ± 0.0
1.202HisTyr: 1.202 ± 0.499
0.0HisXaa: 0.0 ± 0.0
Ile
4.087IleAla: 4.087 ± 0.803
0.481IleCys: 0.481 ± 0.314
6.01IleAsp: 6.01 ± 1.836
9.615IleGlu: 9.615 ± 1.943
3.846IlePhe: 3.846 ± 0.889
3.125IleGly: 3.125 ± 0.952
0.962IleHis: 0.962 ± 0.545
6.01IleIle: 6.01 ± 0.952
8.654IleLys: 8.654 ± 1.415
5.529IleLeu: 5.529 ± 1.212
0.24IleMet: 0.24 ± 0.225
3.365IleAsn: 3.365 ± 1.046
2.404IlePro: 2.404 ± 0.893
2.885IleGln: 2.885 ± 0.735
2.644IleArg: 2.644 ± 0.628
6.25IleSer: 6.25 ± 1.405
3.606IleThr: 3.606 ± 0.926
2.885IleVal: 2.885 ± 0.611
0.481IleTrp: 0.481 ± 0.282
2.885IleTyr: 2.885 ± 0.974
0.0IleXaa: 0.0 ± 0.0
Lys
8.413LysAla: 8.413 ± 1.684
0.481LysCys: 0.481 ± 0.301
4.808LysAsp: 4.808 ± 1.156
9.615LysGlu: 9.615 ± 1.303
2.404LysPhe: 2.404 ± 0.632
2.885LysGly: 2.885 ± 0.731
1.923LysHis: 1.923 ± 0.592
4.808LysIle: 4.808 ± 1.204
6.971LysLys: 6.971 ± 1.232
7.452LysLeu: 7.452 ± 1.288
1.923LysMet: 1.923 ± 0.648
5.288LysAsn: 5.288 ± 1.055
2.885LysPro: 2.885 ± 0.962
3.846LysGln: 3.846 ± 0.746
5.529LysArg: 5.529 ± 1.282
5.288LysSer: 5.288 ± 0.95
6.01LysThr: 6.01 ± 1.491
4.327LysVal: 4.327 ± 0.778
0.721LysTrp: 0.721 ± 0.416
3.125LysTyr: 3.125 ± 0.795
0.0LysXaa: 0.0 ± 0.0
Leu
7.933LeuAla: 7.933 ± 1.455
0.721LeuCys: 0.721 ± 0.465
8.894LeuAsp: 8.894 ± 0.924
13.702LeuGlu: 13.702 ± 1.842
3.846LeuPhe: 3.846 ± 1.099
3.365LeuGly: 3.365 ± 1.076
0.962LeuHis: 0.962 ± 0.552
5.048LeuIle: 5.048 ± 1.036
6.01LeuLys: 6.01 ± 1.261
10.337LeuLeu: 10.337 ± 1.481
2.404LeuMet: 2.404 ± 0.764
7.212LeuAsn: 7.212 ± 1.093
3.846LeuPro: 3.846 ± 0.82
4.567LeuGln: 4.567 ± 0.771
4.567LeuArg: 4.567 ± 1.104
5.288LeuSer: 5.288 ± 1.272
6.25LeuThr: 6.25 ± 1.512
3.606LeuVal: 3.606 ± 1.322
0.481LeuTrp: 0.481 ± 0.309
3.125LeuTyr: 3.125 ± 0.72
0.0LeuXaa: 0.0 ± 0.0
Met
2.404MetAla: 2.404 ± 0.891
0.0MetCys: 0.0 ± 0.0
2.163MetAsp: 2.163 ± 0.676
2.885MetGlu: 2.885 ± 0.875
0.721MetPhe: 0.721 ± 0.385
1.442MetGly: 1.442 ± 0.507
0.24MetHis: 0.24 ± 0.256
1.202MetIle: 1.202 ± 0.48
1.683MetLys: 1.683 ± 0.483
1.442MetLeu: 1.442 ± 0.456
0.24MetMet: 0.24 ± 0.283
2.163MetAsn: 2.163 ± 0.667
0.962MetPro: 0.962 ± 0.494
0.962MetGln: 0.962 ± 0.519
1.442MetArg: 1.442 ± 0.642
1.202MetSer: 1.202 ± 0.441
2.885MetThr: 2.885 ± 1.008
0.962MetVal: 0.962 ± 0.519
0.24MetTrp: 0.24 ± 0.211
0.24MetTyr: 0.24 ± 0.239
0.0MetXaa: 0.0 ± 0.0
Asn
2.885AsnAla: 2.885 ± 0.865
0.24AsnCys: 0.24 ± 0.26
3.125AsnAsp: 3.125 ± 1.068
3.365AsnGlu: 3.365 ± 0.74
1.683AsnPhe: 1.683 ± 0.606
4.808AsnGly: 4.808 ± 0.946
1.683AsnHis: 1.683 ± 0.839
4.327AsnIle: 4.327 ± 1.228
5.769AsnLys: 5.769 ± 1.24
4.327AsnLeu: 4.327 ± 0.864
1.923AsnMet: 1.923 ± 0.647
3.125AsnAsn: 3.125 ± 1.349
2.163AsnPro: 2.163 ± 0.681
2.644AsnGln: 2.644 ± 0.86
1.923AsnArg: 1.923 ± 0.669
3.365AsnSer: 3.365 ± 0.848
5.048AsnThr: 5.048 ± 0.886
2.644AsnVal: 2.644 ± 0.873
0.721AsnTrp: 0.721 ± 0.333
2.644AsnTyr: 2.644 ± 0.775
0.0AsnXaa: 0.0 ± 0.0
Pro
1.202ProAla: 1.202 ± 0.626
0.24ProCys: 0.24 ± 0.211
1.202ProAsp: 1.202 ± 0.519
2.885ProGlu: 2.885 ± 0.737
2.404ProPhe: 2.404 ± 0.786
0.24ProGly: 0.24 ± 0.256
0.0ProHis: 0.0 ± 0.0
1.683ProIle: 1.683 ± 0.503
2.404ProLys: 2.404 ± 0.727
1.442ProLeu: 1.442 ± 0.559
0.24ProMet: 0.24 ± 0.211
1.442ProAsn: 1.442 ± 0.652
1.683ProPro: 1.683 ± 0.681
1.202ProGln: 1.202 ± 0.461
3.606ProArg: 3.606 ± 0.914
1.683ProSer: 1.683 ± 0.618
1.202ProThr: 1.202 ± 0.472
1.923ProVal: 1.923 ± 0.819
0.0ProTrp: 0.0 ± 0.0
1.923ProTyr: 1.923 ± 0.413
0.0ProXaa: 0.0 ± 0.0
Gln
4.327GlnAla: 4.327 ± 1.049
0.24GlnCys: 0.24 ± 0.202
2.163GlnAsp: 2.163 ± 0.794
4.087GlnGlu: 4.087 ± 1.104
1.202GlnPhe: 1.202 ± 0.622
2.163GlnGly: 2.163 ± 0.874
1.202GlnHis: 1.202 ± 0.426
2.163GlnIle: 2.163 ± 0.784
2.644GlnLys: 2.644 ± 0.515
4.808GlnLeu: 4.808 ± 0.971
0.962GlnMet: 0.962 ± 0.533
2.163GlnAsn: 2.163 ± 0.709
0.721GlnPro: 0.721 ± 0.437
1.683GlnGln: 1.683 ± 0.602
2.404GlnArg: 2.404 ± 0.89
1.683GlnSer: 1.683 ± 0.6
2.404GlnThr: 2.404 ± 0.548
3.365GlnVal: 3.365 ± 0.705
0.721GlnTrp: 0.721 ± 0.335
0.481GlnTyr: 0.481 ± 0.271
0.0GlnXaa: 0.0 ± 0.0
Arg
2.163ArgAla: 2.163 ± 0.571
0.24ArgCys: 0.24 ± 0.222
1.923ArgAsp: 1.923 ± 0.616
5.529ArgGlu: 5.529 ± 1.064
2.644ArgPhe: 2.644 ± 0.855
1.683ArgGly: 1.683 ± 0.662
1.202ArgHis: 1.202 ± 0.538
4.087ArgIle: 4.087 ± 0.859
5.048ArgLys: 5.048 ± 0.947
6.971ArgLeu: 6.971 ± 1.344
1.923ArgMet: 1.923 ± 0.81
2.885ArgAsn: 2.885 ± 0.746
0.721ArgPro: 0.721 ± 0.36
3.365ArgGln: 3.365 ± 0.995
1.202ArgArg: 1.202 ± 0.458
1.923ArgSer: 1.923 ± 0.572
3.365ArgThr: 3.365 ± 0.789
2.644ArgVal: 2.644 ± 0.897
0.481ArgTrp: 0.481 ± 0.291
2.644ArgTyr: 2.644 ± 0.686
0.0ArgXaa: 0.0 ± 0.0
Ser
2.163SerAla: 2.163 ± 0.769
0.24SerCys: 0.24 ± 0.256
1.683SerAsp: 1.683 ± 0.551
6.49SerGlu: 6.49 ± 1.722
1.923SerPhe: 1.923 ± 0.623
3.846SerGly: 3.846 ± 0.861
1.202SerHis: 1.202 ± 0.603
4.567SerIle: 4.567 ± 0.937
6.25SerLys: 6.25 ± 1.139
4.567SerLeu: 4.567 ± 1.118
1.202SerMet: 1.202 ± 0.515
4.087SerAsn: 4.087 ± 1.216
2.644SerPro: 2.644 ± 0.69
0.962SerGln: 0.962 ± 0.446
2.404SerArg: 2.404 ± 0.782
2.885SerSer: 2.885 ± 1.002
2.885SerThr: 2.885 ± 0.678
3.606SerVal: 3.606 ± 0.762
0.481SerTrp: 0.481 ± 0.33
2.404SerTyr: 2.404 ± 0.695
0.0SerXaa: 0.0 ± 0.0
Thr
2.404ThrAla: 2.404 ± 0.687
0.0ThrCys: 0.0 ± 0.0
2.163ThrAsp: 2.163 ± 0.749
2.404ThrGlu: 2.404 ± 0.694
1.442ThrPhe: 1.442 ± 0.494
3.846ThrGly: 3.846 ± 0.842
1.202ThrHis: 1.202 ± 0.419
3.365ThrIle: 3.365 ± 0.959
4.567ThrLys: 4.567 ± 1.202
6.49ThrLeu: 6.49 ± 1.222
1.442ThrMet: 1.442 ± 0.576
1.202ThrAsn: 1.202 ± 0.603
2.644ThrPro: 2.644 ± 0.594
2.885ThrGln: 2.885 ± 0.672
1.442ThrArg: 1.442 ± 0.448
4.087ThrSer: 4.087 ± 0.926
3.365ThrThr: 3.365 ± 1.036
5.048ThrVal: 5.048 ± 1.518
0.721ThrTrp: 0.721 ± 0.462
2.885ThrTyr: 2.885 ± 1.109
0.0ThrXaa: 0.0 ± 0.0
Val
2.163ValAla: 2.163 ± 0.905
0.24ValCys: 0.24 ± 0.211
2.644ValAsp: 2.644 ± 0.726
6.25ValGlu: 6.25 ± 1.708
1.202ValPhe: 1.202 ± 0.439
2.404ValGly: 2.404 ± 0.894
0.0ValHis: 0.0 ± 0.0
2.644ValIle: 2.644 ± 1.008
4.087ValLys: 4.087 ± 0.95
4.808ValLeu: 4.808 ± 1.063
1.442ValMet: 1.442 ± 0.68
2.885ValAsn: 2.885 ± 0.688
1.683ValPro: 1.683 ± 0.582
1.683ValGln: 1.683 ± 0.576
3.125ValArg: 3.125 ± 0.786
5.048ValSer: 5.048 ± 0.914
2.404ValThr: 2.404 ± 0.762
3.125ValVal: 3.125 ± 1.001
0.721ValTrp: 0.721 ± 0.482
2.163ValTyr: 2.163 ± 0.662
0.0ValXaa: 0.0 ± 0.0
Trp
0.481TrpAla: 0.481 ± 0.323
0.0TrpCys: 0.0 ± 0.0
0.481TrpAsp: 0.481 ± 0.337
0.962TrpGlu: 0.962 ± 0.486
0.24TrpPhe: 0.24 ± 0.211
0.481TrpGly: 0.481 ± 0.312
0.24TrpHis: 0.24 ± 0.211
0.721TrpIle: 0.721 ± 0.44
0.481TrpLys: 0.481 ± 0.372
0.721TrpLeu: 0.721 ± 0.361
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.481TrpGln: 0.481 ± 0.316
0.481TrpArg: 0.481 ± 0.285
0.721TrpSer: 0.721 ± 0.368
0.24TrpThr: 0.24 ± 0.221
0.962TrpVal: 0.962 ± 0.442
0.0TrpTrp: 0.0 ± 0.0
0.481TrpTyr: 0.481 ± 0.291
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.923TyrAla: 1.923 ± 0.78
0.962TyrCys: 0.962 ± 0.408
1.683TyrAsp: 1.683 ± 0.588
2.644TyrGlu: 2.644 ± 0.701
2.163TyrPhe: 2.163 ± 0.794
0.962TyrGly: 0.962 ± 0.481
0.721TyrHis: 0.721 ± 0.336
3.846TyrIle: 3.846 ± 1.16
5.288TyrLys: 5.288 ± 1.162
7.452TyrLeu: 7.452 ± 1.311
0.721TyrMet: 0.721 ± 0.418
2.644TyrAsn: 2.644 ± 0.912
1.442TyrPro: 1.442 ± 0.791
0.721TyrGln: 0.721 ± 0.427
4.087TyrArg: 4.087 ± 0.801
2.163TyrSer: 2.163 ± 0.586
0.721TyrThr: 0.721 ± 0.317
1.442TyrVal: 1.442 ± 0.6
0.0TyrTrp: 0.0 ± 0.0
1.202TyrTyr: 1.202 ± 0.643
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 29 proteins (4161 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski