Amino acid dipepetide frequency for Streptococcus satellite phage Javan292

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.14AlaAla: 2.14 ± 0.708
0.306AlaCys: 0.306 ± 0.247
7.337AlaAsp: 7.337 ± 1.988
4.891AlaGlu: 4.891 ± 1.722
3.974AlaPhe: 3.974 ± 0.889
3.363AlaGly: 3.363 ± 0.985
0.306AlaHis: 0.306 ± 0.319
6.726AlaIle: 6.726 ± 1.347
7.031AlaLys: 7.031 ± 1.51
5.809AlaLeu: 5.809 ± 1.557
1.529AlaMet: 1.529 ± 0.66
3.057AlaAsn: 3.057 ± 0.837
1.834AlaPro: 1.834 ± 0.626
2.446AlaGln: 2.446 ± 0.835
6.114AlaArg: 6.114 ± 1.487
4.28AlaSer: 4.28 ± 0.929
4.586AlaThr: 4.586 ± 1.187
5.503AlaVal: 5.503 ± 1.159
0.306AlaTrp: 0.306 ± 0.247
3.669AlaTyr: 3.669 ± 1.011
0.0AlaXaa: 0.0 ± 0.0
Cys
0.306CysAla: 0.306 ± 0.308
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.0CysGlu: 0.0 ± 0.0
0.306CysPhe: 0.306 ± 0.4
0.306CysGly: 0.306 ± 0.247
0.306CysHis: 0.306 ± 0.247
0.0CysIle: 0.0 ± 0.0
0.0CysLys: 0.0 ± 0.0
0.306CysLeu: 0.306 ± 0.308
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.306CysPro: 0.306 ± 0.247
0.0CysGln: 0.0 ± 0.0
0.0CysArg: 0.0 ± 0.0
0.611CysSer: 0.611 ± 0.491
0.0CysThr: 0.0 ± 0.0
0.306CysVal: 0.306 ± 0.247
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
1.529AspAla: 1.529 ± 0.728
0.306AspCys: 0.306 ± 0.299
3.363AspAsp: 3.363 ± 0.927
5.503AspGlu: 5.503 ± 1.256
2.446AspPhe: 2.446 ± 0.936
2.446AspGly: 2.446 ± 0.886
0.306AspHis: 0.306 ± 0.247
6.726AspIle: 6.726 ± 1.503
5.197AspLys: 5.197 ± 1.156
6.726AspLeu: 6.726 ± 1.828
1.529AspMet: 1.529 ± 0.652
3.974AspAsn: 3.974 ± 0.836
1.529AspPro: 1.529 ± 0.695
0.306AspGln: 0.306 ± 0.306
3.057AspArg: 3.057 ± 1.163
2.446AspSer: 2.446 ± 1.098
4.891AspThr: 4.891 ± 0.992
3.669AspVal: 3.669 ± 0.741
0.917AspTrp: 0.917 ± 0.517
2.751AspTyr: 2.751 ± 1.028
0.0AspXaa: 0.0 ± 0.0
Glu
7.337GluAla: 7.337 ± 2.025
0.0GluCys: 0.0 ± 0.0
4.586GluAsp: 4.586 ± 1.135
4.28GluGlu: 4.28 ± 1.38
3.057GluPhe: 3.057 ± 1.051
3.974GluGly: 3.974 ± 1.117
1.223GluHis: 1.223 ± 0.615
4.891GluIle: 4.891 ± 0.914
7.337GluLys: 7.337 ± 1.675
8.56GluLeu: 8.56 ± 1.158
1.834GluMet: 1.834 ± 0.735
4.891GluAsn: 4.891 ± 1.014
2.446GluPro: 2.446 ± 0.813
5.809GluGln: 5.809 ± 1.421
6.42GluArg: 6.42 ± 1.371
3.363GluSer: 3.363 ± 1.272
5.809GluThr: 5.809 ± 0.909
5.197GluVal: 5.197 ± 1.203
0.917GluTrp: 0.917 ± 0.475
1.834GluTyr: 1.834 ± 0.879
0.0GluXaa: 0.0 ± 0.0
Phe
1.529PheAla: 1.529 ± 0.499
0.0PheCys: 0.0 ± 0.0
2.446PheAsp: 2.446 ± 0.934
3.363PheGlu: 3.363 ± 0.735
0.611PhePhe: 0.611 ± 0.371
2.751PheGly: 2.751 ± 0.871
1.223PheHis: 1.223 ± 0.44
3.057PheIle: 3.057 ± 1.039
2.446PheLys: 2.446 ± 0.935
5.503PheLeu: 5.503 ± 1.372
0.306PheMet: 0.306 ± 0.3
0.917PheAsn: 0.917 ± 0.492
0.917PhePro: 0.917 ± 0.649
0.306PheGln: 0.306 ± 0.302
1.223PheArg: 1.223 ± 0.452
2.751PheSer: 2.751 ± 1.001
1.529PheThr: 1.529 ± 0.825
1.223PheVal: 1.223 ± 0.782
0.0PheTrp: 0.0 ± 0.0
1.529PheTyr: 1.529 ± 0.708
0.0PheXaa: 0.0 ± 0.0
Gly
3.057GlyAla: 3.057 ± 1.144
0.611GlyCys: 0.611 ± 0.37
1.529GlyAsp: 1.529 ± 0.661
1.529GlyGlu: 1.529 ± 0.571
2.751GlyPhe: 2.751 ± 0.777
2.751GlyGly: 2.751 ± 0.925
1.834GlyHis: 1.834 ± 0.763
4.28GlyIle: 4.28 ± 1.022
5.197GlyLys: 5.197 ± 0.968
6.726GlyLeu: 6.726 ± 1.282
1.529GlyMet: 1.529 ± 0.513
1.834GlyAsn: 1.834 ± 1.048
0.0GlyPro: 0.0 ± 0.0
2.14GlyGln: 2.14 ± 0.833
2.751GlyArg: 2.751 ± 1.152
2.446GlySer: 2.446 ± 0.765
2.14GlyThr: 2.14 ± 0.872
3.363GlyVal: 3.363 ± 1.009
0.917GlyTrp: 0.917 ± 0.617
4.28GlyTyr: 4.28 ± 0.797
0.0GlyXaa: 0.0 ± 0.0
His
1.223HisAla: 1.223 ± 0.839
0.306HisCys: 0.306 ± 0.247
0.611HisAsp: 0.611 ± 0.45
1.529HisGlu: 1.529 ± 0.551
1.223HisPhe: 1.223 ± 0.617
1.834HisGly: 1.834 ± 0.743
0.917HisHis: 0.917 ± 0.787
1.529HisIle: 1.529 ± 0.69
1.529HisLys: 1.529 ± 0.751
2.751HisLeu: 2.751 ± 0.689
0.306HisMet: 0.306 ± 0.302
0.611HisAsn: 0.611 ± 0.4
1.223HisPro: 1.223 ± 0.635
0.306HisGln: 0.306 ± 0.251
1.529HisArg: 1.529 ± 0.649
0.611HisSer: 0.611 ± 0.382
1.223HisThr: 1.223 ± 0.454
0.917HisVal: 0.917 ± 0.561
0.611HisTrp: 0.611 ± 0.465
2.14HisTyr: 2.14 ± 0.659
0.0HisXaa: 0.0 ± 0.0
Ile
6.114IleAla: 6.114 ± 1.861
0.0IleCys: 0.0 ± 0.0
3.974IleAsp: 3.974 ± 0.975
8.254IleGlu: 8.254 ± 1.291
3.363IlePhe: 3.363 ± 1.003
2.14IleGly: 2.14 ± 0.62
2.446IleHis: 2.446 ± 0.839
6.42IleIle: 6.42 ± 1.907
6.42IleLys: 6.42 ± 1.383
7.031IleLeu: 7.031 ± 1.388
0.611IleMet: 0.611 ± 0.419
2.446IleAsn: 2.446 ± 1.207
1.834IlePro: 1.834 ± 0.726
3.057IleGln: 3.057 ± 0.797
3.669IleArg: 3.669 ± 0.746
2.446IleSer: 2.446 ± 0.833
1.834IleThr: 1.834 ± 0.838
4.586IleVal: 4.586 ± 1.06
0.611IleTrp: 0.611 ± 0.408
2.446IleTyr: 2.446 ± 0.65
0.0IleXaa: 0.0 ± 0.0
Lys
7.337LysAla: 7.337 ± 0.964
0.0LysCys: 0.0 ± 0.0
4.586LysAsp: 4.586 ± 1.369
10.7LysGlu: 10.7 ± 1.876
0.917LysPhe: 0.917 ± 0.508
5.197LysGly: 5.197 ± 1.298
1.529LysHis: 1.529 ± 0.481
6.42LysIle: 6.42 ± 1.335
9.477LysLys: 9.477 ± 2.478
6.726LysLeu: 6.726 ± 1.462
0.306LysMet: 0.306 ± 0.228
5.197LysAsn: 5.197 ± 0.994
2.446LysPro: 2.446 ± 0.989
4.28LysGln: 4.28 ± 1.198
3.363LysArg: 3.363 ± 0.88
5.197LysSer: 5.197 ± 1.059
4.28LysThr: 4.28 ± 0.961
4.891LysVal: 4.891 ± 1.515
0.306LysTrp: 0.306 ± 0.38
3.669LysTyr: 3.669 ± 1.153
0.0LysXaa: 0.0 ± 0.0
Leu
11.006LeuAla: 11.006 ± 1.881
0.0LeuCys: 0.0 ± 0.0
7.031LeuAsp: 7.031 ± 1.23
11.923LeuGlu: 11.923 ± 2.111
1.223LeuPhe: 1.223 ± 0.677
7.031LeuGly: 7.031 ± 1.971
1.529LeuHis: 1.529 ± 0.725
1.834LeuIle: 1.834 ± 0.764
9.172LeuLys: 9.172 ± 1.069
7.643LeuLeu: 7.643 ± 2.12
3.057LeuMet: 3.057 ± 1.032
3.363LeuAsn: 3.363 ± 1.062
4.28LeuPro: 4.28 ± 1.073
5.809LeuGln: 5.809 ± 1.165
3.669LeuArg: 3.669 ± 1.012
3.974LeuSer: 3.974 ± 1.275
7.643LeuThr: 7.643 ± 1.414
5.197LeuVal: 5.197 ± 0.968
1.529LeuTrp: 1.529 ± 0.735
4.28LeuTyr: 4.28 ± 0.98
0.0LeuXaa: 0.0 ± 0.0
Met
1.223MetAla: 1.223 ± 0.628
0.0MetCys: 0.0 ± 0.0
1.223MetAsp: 1.223 ± 0.547
1.529MetGlu: 1.529 ± 0.56
0.611MetPhe: 0.611 ± 0.499
0.0MetGly: 0.0 ± 0.0
0.0MetHis: 0.0 ± 0.0
0.611MetIle: 0.611 ± 0.442
1.834MetLys: 1.834 ± 0.721
2.14MetLeu: 2.14 ± 0.822
0.306MetMet: 0.306 ± 0.302
2.14MetAsn: 2.14 ± 0.84
0.611MetPro: 0.611 ± 0.437
0.917MetGln: 0.917 ± 0.519
0.306MetArg: 0.306 ± 0.306
0.306MetSer: 0.306 ± 0.302
2.446MetThr: 2.446 ± 0.833
0.611MetVal: 0.611 ± 0.399
0.0MetTrp: 0.0 ± 0.0
0.917MetTyr: 0.917 ± 0.485
0.0MetXaa: 0.0 ± 0.0
Asn
3.057AsnAla: 3.057 ± 0.872
0.306AsnCys: 0.306 ± 0.308
3.669AsnAsp: 3.669 ± 1.164
1.529AsnGlu: 1.529 ± 0.623
2.446AsnPhe: 2.446 ± 0.603
4.28AsnGly: 4.28 ± 1.031
2.14AsnHis: 2.14 ± 0.839
2.751AsnIle: 2.751 ± 0.833
4.586AsnLys: 4.586 ± 1.437
3.363AsnLeu: 3.363 ± 1.068
0.611AsnMet: 0.611 ± 0.405
0.917AsnAsn: 0.917 ± 0.491
1.834AsnPro: 1.834 ± 0.461
2.751AsnGln: 2.751 ± 0.768
1.529AsnArg: 1.529 ± 0.892
1.834AsnSer: 1.834 ± 0.549
3.363AsnThr: 3.363 ± 0.971
2.446AsnVal: 2.446 ± 0.695
0.611AsnTrp: 0.611 ± 0.464
2.14AsnTyr: 2.14 ± 0.877
0.0AsnXaa: 0.0 ± 0.0
Pro
1.834ProAla: 1.834 ± 0.675
0.0ProCys: 0.0 ± 0.0
1.834ProAsp: 1.834 ± 0.796
2.751ProGlu: 2.751 ± 0.899
0.917ProPhe: 0.917 ± 0.444
1.223ProGly: 1.223 ± 0.518
0.611ProHis: 0.611 ± 0.344
3.057ProIle: 3.057 ± 0.968
1.834ProLys: 1.834 ± 0.937
3.363ProLeu: 3.363 ± 1.026
0.306ProMet: 0.306 ± 0.247
1.223ProAsn: 1.223 ± 0.397
1.834ProPro: 1.834 ± 0.771
0.611ProGln: 0.611 ± 0.392
1.529ProArg: 1.529 ± 0.676
1.223ProSer: 1.223 ± 0.481
2.14ProThr: 2.14 ± 0.82
1.834ProVal: 1.834 ± 0.808
0.917ProTrp: 0.917 ± 0.455
1.834ProTyr: 1.834 ± 0.698
0.0ProXaa: 0.0 ± 0.0
Gln
3.974GlnAla: 3.974 ± 1.093
0.306GlnCys: 0.306 ± 0.247
3.363GlnAsp: 3.363 ± 0.954
3.363GlnGlu: 3.363 ± 0.986
1.223GlnPhe: 1.223 ± 0.599
2.14GlnGly: 2.14 ± 0.86
1.529GlnHis: 1.529 ± 0.601
2.751GlnIle: 2.751 ± 1.156
1.834GlnLys: 1.834 ± 0.913
4.586GlnLeu: 4.586 ± 1.423
0.306GlnMet: 0.306 ± 0.302
2.446GlnAsn: 2.446 ± 0.77
1.223GlnPro: 1.223 ± 0.634
3.057GlnGln: 3.057 ± 1.056
1.834GlnArg: 1.834 ± 0.971
3.363GlnSer: 3.363 ± 1.07
1.529GlnThr: 1.529 ± 0.743
3.057GlnVal: 3.057 ± 0.831
0.611GlnTrp: 0.611 ± 0.385
2.446GlnTyr: 2.446 ± 0.783
0.0GlnXaa: 0.0 ± 0.0
Arg
3.669ArgAla: 3.669 ± 1.12
0.0ArgCys: 0.0 ± 0.0
2.751ArgAsp: 2.751 ± 0.964
3.363ArgGlu: 3.363 ± 0.787
1.529ArgPhe: 1.529 ± 0.555
0.917ArgGly: 0.917 ± 0.42
2.14ArgHis: 2.14 ± 0.679
3.974ArgIle: 3.974 ± 1.033
3.974ArgLys: 3.974 ± 0.872
7.949ArgLeu: 7.949 ± 1.215
0.611ArgMet: 0.611 ± 0.377
1.529ArgAsn: 1.529 ± 0.841
0.611ArgPro: 0.611 ± 0.4
4.586ArgGln: 4.586 ± 1.691
2.751ArgArg: 2.751 ± 0.888
1.529ArgSer: 1.529 ± 0.682
3.363ArgThr: 3.363 ± 1.045
0.611ArgVal: 0.611 ± 0.464
1.223ArgTrp: 1.223 ± 0.627
2.751ArgTyr: 2.751 ± 0.919
0.0ArgXaa: 0.0 ± 0.0
Ser
5.503SerAla: 5.503 ± 0.82
0.0SerCys: 0.0 ± 0.0
3.669SerAsp: 3.669 ± 1.108
3.363SerGlu: 3.363 ± 1.04
0.306SerPhe: 0.306 ± 0.299
1.834SerGly: 1.834 ± 0.976
1.223SerHis: 1.223 ± 0.542
6.114SerIle: 6.114 ± 1.358
4.586SerLys: 4.586 ± 1.244
5.503SerLeu: 5.503 ± 1.587
0.611SerMet: 0.611 ± 0.386
2.751SerAsn: 2.751 ± 0.8
1.529SerPro: 1.529 ± 0.603
1.834SerGln: 1.834 ± 0.714
0.917SerArg: 0.917 ± 0.419
2.751SerSer: 2.751 ± 0.659
2.14SerThr: 2.14 ± 0.744
3.057SerVal: 3.057 ± 1.052
0.306SerTrp: 0.306 ± 0.289
3.669SerTyr: 3.669 ± 1.039
0.0SerXaa: 0.0 ± 0.0
Thr
6.42ThrAla: 6.42 ± 1.194
0.306ThrCys: 0.306 ± 0.4
1.834ThrAsp: 1.834 ± 0.632
6.42ThrGlu: 6.42 ± 2.001
1.223ThrPhe: 1.223 ± 0.591
4.891ThrGly: 4.891 ± 1.099
1.223ThrHis: 1.223 ± 0.496
3.363ThrIle: 3.363 ± 0.851
3.057ThrLys: 3.057 ± 0.839
3.669ThrLeu: 3.669 ± 1.359
1.529ThrMet: 1.529 ± 0.76
2.14ThrAsn: 2.14 ± 0.648
3.057ThrPro: 3.057 ± 0.906
1.834ThrGln: 1.834 ± 0.634
2.751ThrArg: 2.751 ± 1.097
5.197ThrSer: 5.197 ± 0.932
2.751ThrThr: 2.751 ± 0.676
4.891ThrVal: 4.891 ± 1.758
0.0ThrTrp: 0.0 ± 0.0
1.834ThrTyr: 1.834 ± 0.691
0.0ThrXaa: 0.0 ± 0.0
Val
4.891ValAla: 4.891 ± 1.336
0.306ValCys: 0.306 ± 0.308
3.057ValAsp: 3.057 ± 1.03
4.586ValGlu: 4.586 ± 1.423
1.834ValPhe: 1.834 ± 0.896
0.917ValGly: 0.917 ± 0.522
0.611ValHis: 0.611 ± 0.466
3.057ValIle: 3.057 ± 0.83
4.28ValLys: 4.28 ± 1.097
5.809ValLeu: 5.809 ± 1.018
1.529ValMet: 1.529 ± 0.93
4.28ValAsn: 4.28 ± 1.039
1.529ValPro: 1.529 ± 0.538
1.834ValGln: 1.834 ± 0.966
3.057ValArg: 3.057 ± 0.855
3.669ValSer: 3.669 ± 0.822
4.28ValThr: 4.28 ± 0.983
2.14ValVal: 2.14 ± 0.895
0.0ValTrp: 0.0 ± 0.0
3.057ValTyr: 3.057 ± 1.092
0.0ValXaa: 0.0 ± 0.0
Trp
0.611TrpAla: 0.611 ± 0.385
0.0TrpCys: 0.0 ± 0.0
1.223TrpAsp: 1.223 ± 0.461
0.917TrpGlu: 0.917 ± 0.532
0.306TrpPhe: 0.306 ± 0.289
0.306TrpGly: 0.306 ± 0.247
0.0TrpHis: 0.0 ± 0.0
0.306TrpIle: 0.306 ± 0.355
1.529TrpLys: 1.529 ± 0.718
1.529TrpLeu: 1.529 ± 0.507
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.611TrpGln: 0.611 ± 0.452
0.611TrpArg: 0.611 ± 0.574
0.611TrpSer: 0.611 ± 0.324
0.306TrpThr: 0.306 ± 0.302
0.306TrpVal: 0.306 ± 0.283
0.306TrpTrp: 0.306 ± 0.273
0.917TrpTyr: 0.917 ± 0.517
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.446TyrAla: 2.446 ± 0.698
0.0TyrCys: 0.0 ± 0.0
1.529TyrAsp: 1.529 ± 0.632
3.974TyrGlu: 3.974 ± 1.116
3.363TyrPhe: 3.363 ± 1.34
3.363TyrGly: 3.363 ± 0.995
1.834TyrHis: 1.834 ± 0.613
1.834TyrIle: 1.834 ± 0.846
5.503TyrLys: 5.503 ± 1.525
5.503TyrLeu: 5.503 ± 1.207
0.611TyrMet: 0.611 ± 0.385
2.446TyrAsn: 2.446 ± 0.808
1.834TyrPro: 1.834 ± 0.887
2.446TyrGln: 2.446 ± 1.077
2.751TyrArg: 2.751 ± 0.94
3.057TyrSer: 3.057 ± 1.058
2.14TyrThr: 2.14 ± 0.684
1.223TyrVal: 1.223 ± 0.503
0.306TyrTrp: 0.306 ± 0.283
1.834TyrTyr: 1.834 ± 0.581
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 20 proteins (3272 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski