Amino acid dipepetide frequency for Sulfurirhabdus autotrophica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.271AlaAla: 9.271 ± 0.122	1.005AlaCys: 1.005 ± 0.032	4.601AlaAsp: 4.601 ± 0.067	5.861AlaGlu: 5.861 ± 0.091	3.54AlaPhe: 3.54 ± 0.051	7.03AlaGly: 7.03 ± 0.116	2.064AlaHis: 2.064 ± 0.048	5.941AlaIle: 5.941 ± 0.08	4.955AlaLys: 4.955 ± 0.088	10.242AlaLeu: 10.242 ± 0.106	2.803AlaMet: 2.803 ± 0.052	3.564AlaAsn: 3.564 ± 0.064	3.343AlaPro: 3.343 ± 0.055	3.958AlaGln: 3.958 ± 0.064	4.716AlaArg: 4.716 ± 0.075	5.529AlaSer: 5.529 ± 0.081	4.833AlaThr: 4.833 ± 0.083	6.257AlaVal: 6.257 ± 0.071	1.18AlaTrp: 1.18 ± 0.032	2.481AlaTyr: 2.481 ± 0.057	0.0AlaXaa: 0.0 ± 0.0
Cys	0.827CysAla: 0.827 ± 0.028	0.142CysCys: 0.142 ± 0.012	0.548CysAsp: 0.548 ± 0.03	0.54CysGlu: 0.54 ± 0.023	0.332CysPhe: 0.332 ± 0.015	0.909CysGly: 0.909 ± 0.034	0.4CysHis: 0.4 ± 0.055	0.506CysIle: 0.506 ± 0.022	0.4CysLys: 0.4 ± 0.022	0.875CysLeu: 0.875 ± 0.03	0.236CysMet: 0.236 ± 0.014	0.386CysAsn: 0.386 ± 0.018	0.544CysPro: 0.544 ± 0.027	0.329CysGln: 0.329 ± 0.015	0.479CysArg: 0.479 ± 0.018	0.606CysSer: 0.606 ± 0.027	0.52CysThr: 0.52 ± 0.022	0.606CysVal: 0.606 ± 0.022	0.096CysTrp: 0.096 ± 0.009	0.301CysTyr: 0.301 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	4.88AspAla: 4.88 ± 0.066	0.479AspCys: 0.479 ± 0.02	2.482AspAsp: 2.482 ± 0.05	3.466AspGlu: 3.466 ± 0.061	2.306AspPhe: 2.306 ± 0.048	3.613AspGly: 3.613 ± 0.055	1.136AspHis: 1.136 ± 0.032	3.408AspIle: 3.408 ± 0.057	2.699AspLys: 2.699 ± 0.057	5.148AspLeu: 5.148 ± 0.074	1.435AspMet: 1.435 ± 0.038	1.794AspAsn: 1.794 ± 0.038	2.372AspPro: 2.372 ± 0.047	1.836AspGln: 1.836 ± 0.037	2.602AspArg: 2.602 ± 0.047	2.893AspSer: 2.893 ± 0.051	2.632AspThr: 2.632 ± 0.049	3.664AspVal: 3.664 ± 0.063	0.792AspTrp: 0.792 ± 0.026	1.65AspTyr: 1.65 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	5.691GluAla: 5.691 ± 0.096	0.436GluCys: 0.436 ± 0.018	2.555GluAsp: 2.555 ± 0.052	3.428GluGlu: 3.428 ± 0.076	2.252GluPhe: 2.252 ± 0.045	3.706GluGly: 3.706 ± 0.059	1.411GluHis: 1.411 ± 0.037	4.259GluIle: 4.259 ± 0.066	3.832GluLys: 3.832 ± 0.064	6.152GluLeu: 6.152 ± 0.096	1.845GluMet: 1.845 ± 0.04	2.518GluAsn: 2.518 ± 0.046	2.146GluPro: 2.146 ± 0.043	2.915GluGln: 2.915 ± 0.058	3.559GluArg: 3.559 ± 0.069	3.605GluSer: 3.605 ± 0.058	3.274GluThr: 3.274 ± 0.06	4.132GluVal: 4.132 ± 0.067	0.813GluTrp: 0.813 ± 0.029	1.564GluTyr: 1.564 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	3.55PheAla: 3.55 ± 0.057	0.417PheCys: 0.417 ± 0.017	2.411PheAsp: 2.411 ± 0.049	2.266PheGlu: 2.266 ± 0.045	1.765PhePhe: 1.765 ± 0.043	3.283PheGly: 3.283 ± 0.056	0.874PheHis: 0.874 ± 0.028	2.411PheIle: 2.411 ± 0.05	1.83PheLys: 1.83 ± 0.044	3.723PheLeu: 3.723 ± 0.063	1.039PheMet: 1.039 ± 0.03	1.661PheAsn: 1.661 ± 0.041	1.693PhePro: 1.693 ± 0.041	1.364PheGln: 1.364 ± 0.035	1.893PheArg: 1.893 ± 0.045	3.072PheSer: 3.072 ± 0.053	2.262PheThr: 2.262 ± 0.048	2.737PheVal: 2.737 ± 0.049	0.569PheTrp: 0.569 ± 0.019	1.201PheTyr: 1.201 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	5.91GlyAla: 5.91 ± 0.094	0.871GlyCys: 0.871 ± 0.034	3.512GlyAsp: 3.512 ± 0.064	4.271GlyGlu: 4.271 ± 0.065	3.291GlyPhe: 3.291 ± 0.056	5.442GlyGly: 5.442 ± 0.101	1.712GlyHis: 1.712 ± 0.04	4.86GlyIle: 4.86 ± 0.075	4.563GlyLys: 4.563 ± 0.072	7.519GlyLeu: 7.519 ± 0.105	2.334GlyMet: 2.334 ± 0.048	3.024GlyAsn: 3.024 ± 0.084	1.989GlyPro: 1.989 ± 0.046	2.714GlyGln: 2.714 ± 0.052	3.504GlyArg: 3.504 ± 0.065	4.371GlySer: 4.371 ± 0.085	3.947GlyThr: 3.947 ± 0.087	5.456GlyVal: 5.456 ± 0.083	1.098GlyTrp: 1.098 ± 0.03	2.439GlyTyr: 2.439 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	2.13HisAla: 2.13 ± 0.043	0.291HisCys: 0.291 ± 0.018	1.244HisAsp: 1.244 ± 0.038	1.317HisGlu: 1.317 ± 0.038	1.137HisPhe: 1.137 ± 0.033	1.81HisGly: 1.81 ± 0.04	0.681HisHis: 0.681 ± 0.029	1.463HisIle: 1.463 ± 0.043	0.982HisLys: 0.982 ± 0.028	2.339HisLeu: 2.339 ± 0.044	0.561HisMet: 0.561 ± 0.024	0.831HisAsn: 0.831 ± 0.032	1.385HisPro: 1.385 ± 0.038	0.925HisGln: 0.925 ± 0.027	1.146HisArg: 1.146 ± 0.036	1.361HisSer: 1.361 ± 0.032	1.167HisThr: 1.167 ± 0.033	1.431HisVal: 1.431 ± 0.037	0.371HisTrp: 0.371 ± 0.018	0.812HisTyr: 0.812 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	6.295IleAla: 6.295 ± 0.073	0.577IleCys: 0.577 ± 0.025	3.436IleAsp: 3.436 ± 0.056	4.091IleGlu: 4.091 ± 0.069	2.243IlePhe: 2.243 ± 0.046	4.674IleGly: 4.674 ± 0.074	1.366IleHis: 1.366 ± 0.037	3.42IleIle: 3.42 ± 0.068	3.123IleLys: 3.123 ± 0.054	5.649IleLeu: 5.649 ± 0.087	1.373IleMet: 1.373 ± 0.039	2.616IleAsn: 2.616 ± 0.052	3.056IlePro: 3.056 ± 0.054	2.376IleGln: 2.376 ± 0.043	3.059IleArg: 3.059 ± 0.055	4.425IleSer: 4.425 ± 0.066	3.674IleThr: 3.674 ± 0.058	4.098IleVal: 4.098 ± 0.063	0.661IleTrp: 0.661 ± 0.026	1.616IleTyr: 1.616 ± 0.042	0.0IleXaa: 0.0 ± 0.0
Lys	4.521LysAla: 4.521 ± 0.079	0.349LysCys: 0.349 ± 0.025	2.5LysAsp: 2.5 ± 0.048	2.987LysGlu: 2.987 ± 0.065	1.575LysPhe: 1.575 ± 0.039	3.342LysGly: 3.342 ± 0.061	1.182LysHis: 1.182 ± 0.033	3.373LysIle: 3.373 ± 0.061	2.791LysLys: 2.791 ± 0.062	5.615LysLeu: 5.615 ± 0.078	1.56LysMet: 1.56 ± 0.038	2.249LysAsn: 2.249 ± 0.042	2.597LysPro: 2.597 ± 0.054	2.553LysGln: 2.553 ± 0.05	2.774LysArg: 2.774 ± 0.049	3.276LysSer: 3.276 ± 0.056	2.97LysThr: 2.97 ± 0.064	3.47LysVal: 3.47 ± 0.051	0.584LysTrp: 0.584 ± 0.025	1.254LysTyr: 1.254 ± 0.032	0.0LysXaa: 0.0 ± 0.0
Leu	10.544LeuAla: 10.544 ± 0.099	0.917LeuCys: 0.917 ± 0.03	5.685LeuAsp: 5.685 ± 0.079	6.065LeuGlu: 6.065 ± 0.089	4.232LeuPhe: 4.232 ± 0.077	7.279LeuGly: 7.279 ± 0.085	2.398LeuHis: 2.398 ± 0.045	6.005LeuIle: 6.005 ± 0.086	5.521LeuLys: 5.521 ± 0.075	11.11LeuLeu: 11.11 ± 0.123	2.554LeuMet: 2.554 ± 0.053	4.221LeuAsn: 4.221 ± 0.063	5.466LeuPro: 5.466 ± 0.083	4.131LeuGln: 4.131 ± 0.068	5.531LeuArg: 5.531 ± 0.086	7.342LeuSer: 7.342 ± 0.082	5.715LeuThr: 5.715 ± 0.078	6.832LeuVal: 6.832 ± 0.089	1.121LeuTrp: 1.121 ± 0.031	2.532LeuTyr: 2.532 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	2.531MetAla: 2.531 ± 0.042	0.191MetCys: 0.191 ± 0.014	1.351MetAsp: 1.351 ± 0.043	1.47MetGlu: 1.47 ± 0.036	0.849MetPhe: 0.849 ± 0.026	1.953MetGly: 1.953 ± 0.042	0.669MetHis: 0.669 ± 0.025	1.47MetIle: 1.47 ± 0.037	1.505MetLys: 1.505 ± 0.039	2.979MetLeu: 2.979 ± 0.054	0.716MetMet: 0.716 ± 0.029	1.204MetAsn: 1.204 ± 0.038	1.342MetPro: 1.342 ± 0.035	1.314MetGln: 1.314 ± 0.034	1.582MetArg: 1.582 ± 0.038	1.738MetSer: 1.738 ± 0.038	1.42MetThr: 1.42 ± 0.04	1.873MetVal: 1.873 ± 0.041	0.208MetTrp: 0.208 ± 0.015	0.502MetTyr: 0.502 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.714AsnAla: 3.714 ± 0.061	0.4AsnCys: 0.4 ± 0.02	1.934AsnAsp: 1.934 ± 0.045	2.043AsnGlu: 2.043 ± 0.046	1.45AsnPhe: 1.45 ± 0.037	2.942AsnGly: 2.942 ± 0.069	0.897AsnHis: 0.897 ± 0.033	2.559AsnIle: 2.559 ± 0.047	1.856AsnLys: 1.856 ± 0.041	4.277AsnLeu: 4.277 ± 0.06	1.038AsnMet: 1.038 ± 0.029	1.699AsnAsn: 1.699 ± 0.043	2.35AsnPro: 2.35 ± 0.041	1.772AsnGln: 1.772 ± 0.046	2.161AsnArg: 2.161 ± 0.045	2.235AsnSer: 2.235 ± 0.052	2.152AsnThr: 2.152 ± 0.054	2.639AsnVal: 2.639 ± 0.049	0.578AsnTrp: 0.578 ± 0.023	1.094AsnTyr: 1.094 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	4.112ProAla: 4.112 ± 0.069	0.334ProCys: 0.334 ± 0.018	2.915ProAsp: 2.915 ± 0.057	3.53ProGlu: 3.53 ± 0.06	1.882ProPhe: 1.882 ± 0.042	3.331ProGly: 3.331 ± 0.057	1.04ProHis: 1.04 ± 0.027	2.53ProIle: 2.53 ± 0.051	2.066ProLys: 2.066 ± 0.046	4.442ProLeu: 4.442 ± 0.058	1.075ProMet: 1.075 ± 0.033	1.607ProAsn: 1.607 ± 0.038	1.844ProPro: 1.844 ± 0.044	1.799ProGln: 1.799 ± 0.04	1.761ProArg: 1.761 ± 0.041	2.552ProSer: 2.552 ± 0.051	2.173ProThr: 2.173 ± 0.048	3.726ProVal: 3.726 ± 0.06	0.554ProTrp: 0.554 ± 0.021	1.313ProTyr: 1.313 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	4.171GlnAla: 4.171 ± 0.068	0.379GlnCys: 0.379 ± 0.024	1.849GlnAsp: 1.849 ± 0.048	2.411GlnGlu: 2.411 ± 0.055	1.598GlnPhe: 1.598 ± 0.036	2.806GlnGly: 2.806 ± 0.051	1.075GlnHis: 1.075 ± 0.031	2.589GlnIle: 2.589 ± 0.052	2.023GlnLys: 2.023 ± 0.047	4.31GlnLeu: 4.31 ± 0.066	1.047GlnMet: 1.047 ± 0.031	1.639GlnAsn: 1.639 ± 0.035	1.891GlnPro: 1.891 ± 0.041	2.024GlnGln: 2.024 ± 0.044	2.334GlnArg: 2.334 ± 0.052	2.554GlnSer: 2.554 ± 0.047	2.217GlnThr: 2.217 ± 0.043	2.882GlnVal: 2.882 ± 0.06	0.508GlnTrp: 0.508 ± 0.022	1.115GlnTyr: 1.115 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	4.271ArgAla: 4.271 ± 0.065	0.475ArgCys: 0.475 ± 0.02	2.72ArgAsp: 2.72 ± 0.057	3.592ArgGlu: 3.592 ± 0.061	2.444ArgPhe: 2.444 ± 0.055	3.068ArgGly: 3.068 ± 0.06	1.329ArgHis: 1.329 ± 0.031	3.55ArgIle: 3.55 ± 0.055	2.648ArgLys: 2.648 ± 0.055	5.853ArgLeu: 5.853 ± 0.088	1.471ArgMet: 1.471 ± 0.032	2.238ArgAsn: 2.238 ± 0.044	1.97ArgPro: 1.97 ± 0.039	2.203ArgGln: 2.203 ± 0.051	2.899ArgArg: 2.899 ± 0.075	2.751ArgSer: 2.751 ± 0.052	2.391ArgThr: 2.391 ± 0.04	3.479ArgVal: 3.479 ± 0.059	0.702ArgTrp: 0.702 ± 0.026	1.859ArgTyr: 1.859 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	5.72SerAla: 5.72 ± 0.076	0.638SerCys: 0.638 ± 0.031	3.124SerAsp: 3.124 ± 0.054	3.702SerGlu: 3.702 ± 0.06	2.494SerPhe: 2.494 ± 0.048	5.616SerGly: 5.616 ± 0.087	1.48SerHis: 1.48 ± 0.034	3.801SerIle: 3.801 ± 0.064	3.046SerLys: 3.046 ± 0.057	6.608SerLeu: 6.608 ± 0.074	1.604SerMet: 1.604 ± 0.04	2.465SerAsn: 2.465 ± 0.059	2.745SerPro: 2.745 ± 0.053	2.519SerGln: 2.519 ± 0.043	3.242SerArg: 3.242 ± 0.057	3.928SerSer: 3.928 ± 0.074	3.305SerThr: 3.305 ± 0.078	4.289SerVal: 4.289 ± 0.058	0.799SerTrp: 0.799 ± 0.024	1.616SerTyr: 1.616 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	4.834ThrAla: 4.834 ± 0.081	0.554ThrCys: 0.554 ± 0.04	2.653ThrAsp: 2.653 ± 0.045	2.764ThrGlu: 2.764 ± 0.052	2.018ThrPhe: 2.018 ± 0.042	4.582ThrGly: 4.582 ± 0.083	1.255ThrHis: 1.255 ± 0.037	3.233ThrIle: 3.233 ± 0.061	2.237ThrLys: 2.237 ± 0.044	6.3ThrLeu: 6.3 ± 0.086	1.206ThrMet: 1.206 ± 0.034	1.868ThrAsn: 1.868 ± 0.048	3.035ThrPro: 3.035 ± 0.058	2.248ThrGln: 2.248 ± 0.045	2.636ThrArg: 2.636 ± 0.044	3.299ThrSer: 3.299 ± 0.079	3.021ThrThr: 3.021 ± 0.081	3.789ThrVal: 3.789 ± 0.063	0.668ThrTrp: 0.668 ± 0.024	1.481ThrTyr: 1.481 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	6.79ValAla: 6.79 ± 0.077	0.659ValCys: 0.659 ± 0.023	3.702ValAsp: 3.702 ± 0.065	4.204ValGlu: 4.204 ± 0.07	2.759ValPhe: 2.759 ± 0.053	4.526ValGly: 4.526 ± 0.077	1.356ValHis: 1.356 ± 0.036	4.339ValIle: 4.339 ± 0.064	3.637ValLys: 3.637 ± 0.063	7.251ValLeu: 7.251 ± 0.096	1.959ValMet: 1.959 ± 0.048	2.745ValAsn: 2.745 ± 0.056	2.987ValPro: 2.987 ± 0.06	2.359ValGln: 2.359 ± 0.048	3.49ValArg: 3.49 ± 0.053	4.806ValSer: 4.806 ± 0.068	4.021ValThr: 4.021 ± 0.066	5.339ValVal: 5.339 ± 0.078	0.846ValTrp: 0.846 ± 0.028	1.702ValTyr: 1.702 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	0.951TrpAla: 0.951 ± 0.029	0.155TrpCys: 0.155 ± 0.011	0.591TrpAsp: 0.591 ± 0.025	0.653TrpGlu: 0.653 ± 0.023	0.563TrpPhe: 0.563 ± 0.024	0.795TrpGly: 0.795 ± 0.026	0.386TrpHis: 0.386 ± 0.02	0.726TrpIle: 0.726 ± 0.024	0.624TrpLys: 0.624 ± 0.023	1.746TrpLeu: 1.746 ± 0.039	0.387TrpMet: 0.387 ± 0.018	0.462TrpAsn: 0.462 ± 0.023	0.481TrpPro: 0.481 ± 0.022	0.747TrpGln: 0.747 ± 0.032	0.817TrpArg: 0.817 ± 0.028	0.683TrpSer: 0.683 ± 0.022	0.509TrpThr: 0.509 ± 0.022	0.986TrpVal: 0.986 ± 0.031	0.213TrpTrp: 0.213 ± 0.015	0.334TrpTyr: 0.334 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.462TyrAla: 2.462 ± 0.053	0.314TyrCys: 0.314 ± 0.015	1.47TyrAsp: 1.47 ± 0.046	1.434TyrGlu: 1.434 ± 0.039	1.288TyrPhe: 1.288 ± 0.038	2.122TyrGly: 2.122 ± 0.046	0.672TyrHis: 0.672 ± 0.021	1.389TyrIle: 1.389 ± 0.036	1.185TyrLys: 1.185 ± 0.037	3.063TyrLeu: 3.063 ± 0.055	0.62TyrMet: 0.62 ± 0.025	0.999TyrAsn: 0.999 ± 0.032	1.349TyrPro: 1.349 ± 0.03	1.337TyrGln: 1.337 ± 0.032	1.726TyrArg: 1.726 ± 0.042	1.718TyrSer: 1.718 ± 0.041	1.477TyrThr: 1.477 ± 0.043	1.794TyrVal: 1.794 ± 0.043	0.448TyrTrp: 0.448 ± 0.019	0.924TyrTyr: 0.924 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3698 proteins (1141177 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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