Amino acid dipepetide frequency for Streptococcus phage Javan554

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.267AlaAla: 4.267 ± 1.245
0.435AlaCys: 0.435 ± 0.196
4.354AlaAsp: 4.354 ± 0.642
4.876AlaGlu: 4.876 ± 0.597
3.57AlaPhe: 3.57 ± 0.881
5.486AlaGly: 5.486 ± 1.408
0.435AlaHis: 0.435 ± 0.195
5.051AlaIle: 5.051 ± 1.038
6.183AlaLys: 6.183 ± 0.815
6.27AlaLeu: 6.27 ± 1.06
1.567AlaMet: 1.567 ± 0.485
3.135AlaAsn: 3.135 ± 0.411
2.003AlaPro: 2.003 ± 0.391
4.006AlaGln: 4.006 ± 0.917
2.525AlaArg: 2.525 ± 0.562
5.138AlaSer: 5.138 ± 1.097
4.789AlaThr: 4.789 ± 0.782
5.573AlaVal: 5.573 ± 1.173
1.306AlaTrp: 1.306 ± 0.246
2.177AlaTyr: 2.177 ± 0.406
0.0AlaXaa: 0.0 ± 0.0
Cys
0.174CysAla: 0.174 ± 0.106
0.087CysCys: 0.087 ± 0.096
0.435CysAsp: 0.435 ± 0.198
0.61CysGlu: 0.61 ± 0.217
0.087CysPhe: 0.087 ± 0.087
0.174CysGly: 0.174 ± 0.128
0.087CysHis: 0.087 ± 0.079
0.174CysIle: 0.174 ± 0.121
0.087CysLys: 0.087 ± 0.107
0.784CysLeu: 0.784 ± 0.3
0.261CysMet: 0.261 ± 0.144
0.087CysAsn: 0.087 ± 0.085
0.087CysPro: 0.087 ± 0.086
0.348CysGln: 0.348 ± 0.146
0.261CysArg: 0.261 ± 0.139
0.174CysSer: 0.174 ± 0.115
0.174CysThr: 0.174 ± 0.12
0.174CysVal: 0.174 ± 0.115
0.0CysTrp: 0.0 ± 0.0
0.435CysTyr: 0.435 ± 0.206
0.0CysXaa: 0.0 ± 0.0
Asp
2.699AspAla: 2.699 ± 0.595
0.61AspCys: 0.61 ± 0.238
3.657AspAsp: 3.657 ± 0.569
4.876AspGlu: 4.876 ± 0.975
3.483AspPhe: 3.483 ± 0.491
5.747AspGly: 5.747 ± 0.811
0.697AspHis: 0.697 ± 0.21
4.006AspIle: 4.006 ± 0.641
5.486AspLys: 5.486 ± 0.649
4.789AspLeu: 4.789 ± 0.688
1.567AspMet: 1.567 ± 0.319
4.441AspAsn: 4.441 ± 0.571
1.829AspPro: 1.829 ± 0.436
1.654AspGln: 1.654 ± 0.32
1.829AspArg: 1.829 ± 0.434
4.354AspSer: 4.354 ± 0.554
3.744AspThr: 3.744 ± 0.529
4.267AspVal: 4.267 ± 0.648
0.61AspTrp: 0.61 ± 0.217
2.264AspTyr: 2.264 ± 0.586
0.0AspXaa: 0.0 ± 0.0
Glu
4.789GluAla: 4.789 ± 0.594
0.261GluCys: 0.261 ± 0.183
3.57GluAsp: 3.57 ± 0.685
5.138GluGlu: 5.138 ± 0.935
1.916GluPhe: 1.916 ± 0.479
3.135GluGly: 3.135 ± 0.471
1.393GluHis: 1.393 ± 0.313
6.792GluIle: 6.792 ± 1.032
4.876GluLys: 4.876 ± 0.655
6.183GluLeu: 6.183 ± 0.877
2.003GluMet: 2.003 ± 0.395
3.483GluAsn: 3.483 ± 0.535
1.829GluPro: 1.829 ± 0.448
3.222GluGln: 3.222 ± 0.557
4.615GluArg: 4.615 ± 0.519
4.18GluSer: 4.18 ± 0.747
3.309GluThr: 3.309 ± 0.579
4.876GluVal: 4.876 ± 0.689
0.958GluTrp: 0.958 ± 0.304
3.657GluTyr: 3.657 ± 0.568
0.0GluXaa: 0.0 ± 0.0
Phe
2.786PheAla: 2.786 ± 0.531
0.087PheCys: 0.087 ± 0.095
3.744PheAsp: 3.744 ± 0.66
3.744PheGlu: 3.744 ± 0.62
1.742PhePhe: 1.742 ± 0.45
2.874PheGly: 2.874 ± 0.492
0.435PheHis: 0.435 ± 0.201
2.003PheIle: 2.003 ± 0.386
3.744PheLys: 3.744 ± 0.519
2.09PheLeu: 2.09 ± 0.421
0.958PheMet: 0.958 ± 0.251
2.961PheAsn: 2.961 ± 0.457
1.045PhePro: 1.045 ± 0.268
1.916PheGln: 1.916 ± 0.391
2.612PheArg: 2.612 ± 0.454
3.222PheSer: 3.222 ± 0.511
2.612PheThr: 2.612 ± 0.555
2.786PheVal: 2.786 ± 0.523
0.697PheTrp: 0.697 ± 0.214
1.48PheTyr: 1.48 ± 0.397
0.0PheXaa: 0.0 ± 0.0
Gly
5.921GlyAla: 5.921 ± 1.328
0.435GlyCys: 0.435 ± 0.225
3.831GlyAsp: 3.831 ± 0.512
3.657GlyGlu: 3.657 ± 0.488
2.786GlyPhe: 2.786 ± 0.557
4.702GlyGly: 4.702 ± 0.653
1.393GlyHis: 1.393 ± 0.394
5.051GlyIle: 5.051 ± 1.541
5.051GlyLys: 5.051 ± 0.402
5.573GlyLeu: 5.573 ± 1.181
2.177GlyMet: 2.177 ± 0.605
3.396GlyAsn: 3.396 ± 0.612
1.219GlyPro: 1.219 ± 0.315
2.961GlyGln: 2.961 ± 0.426
3.831GlyArg: 3.831 ± 0.67
3.831GlySer: 3.831 ± 0.714
4.441GlyThr: 4.441 ± 0.761
5.399GlyVal: 5.399 ± 0.856
0.697GlyTrp: 0.697 ± 0.261
2.09GlyTyr: 2.09 ± 0.528
0.0GlyXaa: 0.0 ± 0.0
His
1.045HisAla: 1.045 ± 0.262
0.087HisCys: 0.087 ± 0.084
0.958HisAsp: 0.958 ± 0.288
0.958HisGlu: 0.958 ± 0.271
0.871HisPhe: 0.871 ± 0.316
1.393HisGly: 1.393 ± 0.344
0.261HisHis: 0.261 ± 0.152
0.697HisIle: 0.697 ± 0.219
0.958HisLys: 0.958 ± 0.31
1.045HisLeu: 1.045 ± 0.24
0.522HisMet: 0.522 ± 0.181
0.871HisAsn: 0.871 ± 0.23
1.045HisPro: 1.045 ± 0.277
0.522HisGln: 0.522 ± 0.173
0.348HisArg: 0.348 ± 0.151
0.435HisSer: 0.435 ± 0.148
0.871HisThr: 0.871 ± 0.276
0.784HisVal: 0.784 ± 0.287
0.435HisTrp: 0.435 ± 0.171
0.435HisTyr: 0.435 ± 0.171
0.0HisXaa: 0.0 ± 0.0
Ile
4.876IleAla: 4.876 ± 0.776
0.522IleCys: 0.522 ± 0.199
5.747IleAsp: 5.747 ± 0.644
5.312IleGlu: 5.312 ± 0.604
2.612IlePhe: 2.612 ± 0.434
4.789IleGly: 4.789 ± 1.078
1.045IleHis: 1.045 ± 0.258
3.744IleIle: 3.744 ± 0.717
5.486IleLys: 5.486 ± 0.626
4.528IleLeu: 4.528 ± 0.645
0.958IleMet: 0.958 ± 0.323
3.048IleAsn: 3.048 ± 0.453
2.525IlePro: 2.525 ± 0.62
2.264IleGln: 2.264 ± 0.38
3.483IleArg: 3.483 ± 0.482
4.615IleSer: 4.615 ± 0.823
4.267IleThr: 4.267 ± 0.566
6.008IleVal: 6.008 ± 0.812
0.174IleTrp: 0.174 ± 0.118
2.612IleTyr: 2.612 ± 0.578
0.0IleXaa: 0.0 ± 0.0
Lys
5.051LysAla: 5.051 ± 0.915
0.174LysCys: 0.174 ± 0.111
3.048LysAsp: 3.048 ± 0.584
5.225LysGlu: 5.225 ± 0.822
2.874LysPhe: 2.874 ± 0.494
5.486LysGly: 5.486 ± 0.639
1.829LysHis: 1.829 ± 0.456
5.486LysIle: 5.486 ± 0.551
7.227LysLys: 7.227 ± 1.05
5.138LysLeu: 5.138 ± 0.645
1.132LysMet: 1.132 ± 0.33
4.093LysAsn: 4.093 ± 0.673
2.525LysPro: 2.525 ± 0.472
3.396LysGln: 3.396 ± 0.519
3.831LysArg: 3.831 ± 0.734
4.789LysSer: 4.789 ± 0.572
5.051LysThr: 5.051 ± 0.798
6.008LysVal: 6.008 ± 0.908
1.132LysTrp: 1.132 ± 0.376
2.612LysTyr: 2.612 ± 0.615
0.0LysXaa: 0.0 ± 0.0
Leu
7.053LeuAla: 7.053 ± 1.132
0.261LeuCys: 0.261 ± 0.145
4.789LeuAsp: 4.789 ± 0.434
7.053LeuGlu: 7.053 ± 0.832
3.309LeuPhe: 3.309 ± 0.538
4.702LeuGly: 4.702 ± 0.611
1.219LeuHis: 1.219 ± 0.363
3.831LeuIle: 3.831 ± 0.428
6.183LeuLys: 6.183 ± 0.747
5.399LeuLeu: 5.399 ± 0.549
1.48LeuMet: 1.48 ± 0.354
5.66LeuAsn: 5.66 ± 0.594
2.351LeuPro: 2.351 ± 0.461
2.786LeuGln: 2.786 ± 0.406
3.048LeuArg: 3.048 ± 0.635
5.138LeuSer: 5.138 ± 1.06
5.921LeuThr: 5.921 ± 0.891
4.354LeuVal: 4.354 ± 0.674
0.697LeuTrp: 0.697 ± 0.257
1.829LeuTyr: 1.829 ± 0.415
0.0LeuXaa: 0.0 ± 0.0
Met
1.654MetAla: 1.654 ± 0.36
0.087MetCys: 0.087 ± 0.084
1.306MetAsp: 1.306 ± 0.336
1.654MetGlu: 1.654 ± 0.38
1.132MetPhe: 1.132 ± 0.298
0.871MetGly: 0.871 ± 0.25
0.087MetHis: 0.087 ± 0.087
1.742MetIle: 1.742 ± 0.415
1.48MetLys: 1.48 ± 0.311
2.003MetLeu: 2.003 ± 0.325
0.435MetMet: 0.435 ± 0.261
1.132MetAsn: 1.132 ± 0.333
0.435MetPro: 0.435 ± 0.214
0.958MetGln: 0.958 ± 0.243
1.132MetArg: 1.132 ± 0.25
1.393MetSer: 1.393 ± 0.461
2.525MetThr: 2.525 ± 0.324
1.742MetVal: 1.742 ± 0.447
0.261MetTrp: 0.261 ± 0.142
1.045MetTyr: 1.045 ± 0.239
0.0MetXaa: 0.0 ± 0.0
Asn
4.354AsnAla: 4.354 ± 0.808
0.348AsnCys: 0.348 ± 0.147
4.354AsnAsp: 4.354 ± 0.69
3.57AsnGlu: 3.57 ± 0.746
2.177AsnPhe: 2.177 ± 0.38
4.441AsnGly: 4.441 ± 0.537
0.435AsnHis: 0.435 ± 0.183
3.483AsnIle: 3.483 ± 0.451
4.006AsnLys: 4.006 ± 0.636
3.831AsnLeu: 3.831 ± 0.419
1.742AsnMet: 1.742 ± 0.368
3.657AsnAsn: 3.657 ± 0.471
2.699AsnPro: 2.699 ± 0.485
3.135AsnGln: 3.135 ± 0.525
2.351AsnArg: 2.351 ± 0.523
3.048AsnSer: 3.048 ± 0.51
2.438AsnThr: 2.438 ± 0.522
3.918AsnVal: 3.918 ± 0.468
0.61AsnTrp: 0.61 ± 0.226
1.742AsnTyr: 1.742 ± 0.441
0.0AsnXaa: 0.0 ± 0.0
Pro
2.351ProAla: 2.351 ± 0.377
0.087ProCys: 0.087 ± 0.089
2.003ProAsp: 2.003 ± 0.376
2.177ProGlu: 2.177 ± 0.377
1.48ProPhe: 1.48 ± 0.427
1.654ProGly: 1.654 ± 0.278
0.784ProHis: 0.784 ± 0.296
1.654ProIle: 1.654 ± 0.38
2.874ProLys: 2.874 ± 0.584
2.961ProLeu: 2.961 ± 0.481
0.958ProMet: 0.958 ± 0.229
2.177ProAsn: 2.177 ± 0.482
0.435ProPro: 0.435 ± 0.191
0.871ProGln: 0.871 ± 0.268
0.958ProArg: 0.958 ± 0.34
1.48ProSer: 1.48 ± 0.409
1.306ProThr: 1.306 ± 0.293
2.264ProVal: 2.264 ± 0.417
0.348ProTrp: 0.348 ± 0.147
1.306ProTyr: 1.306 ± 0.334
0.0ProXaa: 0.0 ± 0.0
Gln
4.615GlnAla: 4.615 ± 1.034
0.087GlnCys: 0.087 ± 0.079
1.829GlnAsp: 1.829 ± 0.434
2.525GlnGlu: 2.525 ± 0.429
1.742GlnPhe: 1.742 ± 0.384
2.09GlnGly: 2.09 ± 0.666
0.435GlnHis: 0.435 ± 0.277
3.048GlnIle: 3.048 ± 0.595
2.177GlnLys: 2.177 ± 0.432
3.657GlnLeu: 3.657 ± 0.499
1.219GlnMet: 1.219 ± 0.236
2.003GlnAsn: 2.003 ± 0.342
0.871GlnPro: 0.871 ± 0.229
1.567GlnGln: 1.567 ± 0.409
1.742GlnArg: 1.742 ± 0.477
2.874GlnSer: 2.874 ± 0.509
2.438GlnThr: 2.438 ± 0.387
2.961GlnVal: 2.961 ± 0.398
0.435GlnTrp: 0.435 ± 0.161
1.654GlnTyr: 1.654 ± 0.322
0.0GlnXaa: 0.0 ± 0.0
Arg
2.874ArgAla: 2.874 ± 0.417
0.0ArgCys: 0.0 ± 0.0
2.786ArgAsp: 2.786 ± 0.493
2.961ArgGlu: 2.961 ± 0.548
1.567ArgPhe: 1.567 ± 0.316
2.525ArgGly: 2.525 ± 0.367
0.871ArgHis: 0.871 ± 0.264
3.57ArgIle: 3.57 ± 0.592
3.831ArgLys: 3.831 ± 0.628
4.093ArgLeu: 4.093 ± 0.596
1.219ArgMet: 1.219 ± 0.369
2.438ArgAsn: 2.438 ± 0.583
1.219ArgPro: 1.219 ± 0.307
2.003ArgGln: 2.003 ± 0.466
2.09ArgArg: 2.09 ± 0.636
3.135ArgSer: 3.135 ± 0.456
2.961ArgThr: 2.961 ± 0.613
2.003ArgVal: 2.003 ± 0.37
0.958ArgTrp: 0.958 ± 0.358
2.264ArgTyr: 2.264 ± 0.408
0.0ArgXaa: 0.0 ± 0.0
Ser
4.528SerAla: 4.528 ± 1.076
0.087SerCys: 0.087 ± 0.087
4.267SerAsp: 4.267 ± 0.532
4.528SerGlu: 4.528 ± 0.558
2.786SerPhe: 2.786 ± 0.472
5.399SerGly: 5.399 ± 1.09
0.61SerHis: 0.61 ± 0.228
4.702SerIle: 4.702 ± 0.632
4.18SerLys: 4.18 ± 0.579
4.789SerLeu: 4.789 ± 0.704
1.916SerMet: 1.916 ± 0.427
3.831SerAsn: 3.831 ± 0.684
2.786SerPro: 2.786 ± 0.43
2.699SerGln: 2.699 ± 0.662
2.961SerArg: 2.961 ± 0.436
5.138SerSer: 5.138 ± 0.761
3.831SerThr: 3.831 ± 0.791
3.657SerVal: 3.657 ± 0.447
0.784SerTrp: 0.784 ± 0.256
2.264SerTyr: 2.264 ± 0.553
0.0SerXaa: 0.0 ± 0.0
Thr
4.702ThrAla: 4.702 ± 0.856
0.261ThrCys: 0.261 ± 0.181
3.483ThrAsp: 3.483 ± 0.616
4.006ThrGlu: 4.006 ± 0.766
3.744ThrPhe: 3.744 ± 0.576
5.921ThrGly: 5.921 ± 0.772
0.871ThrHis: 0.871 ± 0.251
5.66ThrIle: 5.66 ± 0.954
3.918ThrLys: 3.918 ± 0.517
4.702ThrLeu: 4.702 ± 0.75
0.871ThrMet: 0.871 ± 0.245
2.961ThrAsn: 2.961 ± 0.429
2.09ThrPro: 2.09 ± 0.413
1.567ThrGln: 1.567 ± 0.401
1.48ThrArg: 1.48 ± 0.403
3.918ThrSer: 3.918 ± 0.845
3.57ThrThr: 3.57 ± 0.611
5.051ThrVal: 5.051 ± 0.792
0.871ThrTrp: 0.871 ± 0.318
2.351ThrTyr: 2.351 ± 0.544
0.0ThrXaa: 0.0 ± 0.0
Val
5.921ValAla: 5.921 ± 0.977
0.261ValCys: 0.261 ± 0.155
5.138ValAsp: 5.138 ± 0.645
4.006ValGlu: 4.006 ± 0.681
2.874ValPhe: 2.874 ± 0.485
4.615ValGly: 4.615 ± 0.752
0.871ValHis: 0.871 ± 0.252
4.615ValIle: 4.615 ± 0.52
4.615ValLys: 4.615 ± 0.657
5.138ValLeu: 5.138 ± 0.619
1.306ValMet: 1.306 ± 0.333
4.18ValAsn: 4.18 ± 0.678
1.654ValPro: 1.654 ± 0.309
2.264ValGln: 2.264 ± 0.511
3.57ValArg: 3.57 ± 0.757
5.486ValSer: 5.486 ± 0.658
4.789ValThr: 4.789 ± 0.73
4.441ValVal: 4.441 ± 0.695
1.219ValTrp: 1.219 ± 0.405
2.264ValTyr: 2.264 ± 0.53
0.0ValXaa: 0.0 ± 0.0
Trp
1.219TrpAla: 1.219 ± 0.317
0.174TrpCys: 0.174 ± 0.123
1.045TrpAsp: 1.045 ± 0.355
1.132TrpGlu: 1.132 ± 0.326
0.784TrpPhe: 0.784 ± 0.222
0.61TrpGly: 0.61 ± 0.238
0.087TrpHis: 0.087 ± 0.107
0.522TrpIle: 0.522 ± 0.246
1.045TrpLys: 1.045 ± 0.319
0.784TrpLeu: 0.784 ± 0.253
0.174TrpMet: 0.174 ± 0.121
0.348TrpAsn: 0.348 ± 0.137
0.087TrpPro: 0.087 ± 0.088
0.61TrpGln: 0.61 ± 0.292
0.871TrpArg: 0.871 ± 0.229
0.871TrpSer: 0.871 ± 0.276
1.132TrpThr: 1.132 ± 0.277
0.435TrpVal: 0.435 ± 0.208
0.087TrpTrp: 0.087 ± 0.074
0.435TrpTyr: 0.435 ± 0.222
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.264TyrAla: 2.264 ± 0.528
0.348TyrCys: 0.348 ± 0.157
2.264TyrAsp: 2.264 ± 0.526
2.264TyrGlu: 2.264 ± 0.498
2.003TyrPhe: 2.003 ± 0.423
1.829TyrGly: 1.829 ± 0.425
0.697TyrHis: 0.697 ± 0.253
2.786TyrIle: 2.786 ± 0.404
2.699TyrLys: 2.699 ± 0.562
3.309TyrLeu: 3.309 ± 0.595
0.522TyrMet: 0.522 ± 0.207
2.438TyrAsn: 2.438 ± 0.491
1.393TyrPro: 1.393 ± 0.272
1.219TyrGln: 1.219 ± 0.265
1.829TyrArg: 1.829 ± 0.382
2.525TyrSer: 2.525 ± 0.446
1.829TyrThr: 1.829 ± 0.502
2.525TyrVal: 2.525 ± 0.355
0.174TyrTrp: 0.174 ± 0.114
1.829TyrTyr: 1.829 ± 0.536
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 52 proteins (11485 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski