Amino acid dipepetide frequency for Exidia glandulosa HHB12029

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.488AlaAla: 11.488 ± 0.053	1.43AlaCys: 1.43 ± 0.014	4.904AlaAsp: 4.904 ± 0.025	4.923AlaGlu: 4.923 ± 0.024	3.829AlaPhe: 3.829 ± 0.022	5.966AlaGly: 5.966 ± 0.027	2.685AlaHis: 2.685 ± 0.017	3.96AlaIle: 3.96 ± 0.02	3.602AlaLys: 3.602 ± 0.023	10.604AlaLeu: 10.604 ± 0.042	2.105AlaMet: 2.105 ± 0.016	2.708AlaAsn: 2.708 ± 0.018	6.775AlaPro: 6.775 ± 0.038	3.955AlaGln: 3.955 ± 0.025	7.049AlaArg: 7.049 ± 0.031	8.271AlaSer: 8.271 ± 0.033	6.094AlaThr: 6.094 ± 0.03	6.675AlaVal: 6.675 ± 0.027	1.401AlaTrp: 1.401 ± 0.012	2.417AlaTyr: 2.417 ± 0.017	0.0AlaXaa: 0.0 ± 0.0
Cys	1.454CysAla: 1.454 ± 0.014	0.315CysCys: 0.315 ± 0.007	0.814CysAsp: 0.814 ± 0.01	0.629CysGlu: 0.629 ± 0.009	0.545CysPhe: 0.545 ± 0.009	1.071CysGly: 1.071 ± 0.015	0.339CysHis: 0.339 ± 0.006	0.727CysIle: 0.727 ± 0.009	0.524CysLys: 0.524 ± 0.008	1.302CysLeu: 1.302 ± 0.012	0.31CysMet: 0.31 ± 0.006	0.446CysAsn: 0.446 ± 0.007	0.935CysPro: 0.935 ± 0.012	0.434CysGln: 0.434 ± 0.007	0.981CysArg: 0.981 ± 0.011	1.154CysSer: 1.154 ± 0.013	0.977CysThr: 0.977 ± 0.011	1.026CysVal: 1.026 ± 0.011	0.234CysTrp: 0.234 ± 0.005	0.329CysTyr: 0.329 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	6.479AspAla: 6.479 ± 0.033	0.764AspCys: 0.764 ± 0.01	4.894AspAsp: 4.894 ± 0.036	4.274AspGlu: 4.274 ± 0.028	2.165AspPhe: 2.165 ± 0.017	4.252AspGly: 4.252 ± 0.024	1.177AspHis: 1.177 ± 0.013	2.868AspIle: 2.868 ± 0.018	1.896AspLys: 1.896 ± 0.017	5.029AspLeu: 5.029 ± 0.022	1.236AspMet: 1.236 ± 0.012	1.592AspAsn: 1.592 ± 0.013	3.418AspPro: 3.418 ± 0.019	1.425AspGln: 1.425 ± 0.011	2.916AspArg: 2.916 ± 0.02	3.898AspSer: 3.898 ± 0.022	3.024AspThr: 3.024 ± 0.019	4.532AspVal: 4.532 ± 0.022	0.978AspTrp: 0.978 ± 0.01	1.423AspTyr: 1.423 ± 0.014	0.0AspXaa: 0.0 ± 0.0
Glu	4.64GluAla: 4.64 ± 0.027	0.687GluCys: 0.687 ± 0.009	3.702GluAsp: 3.702 ± 0.026	4.093GluGlu: 4.093 ± 0.036	1.734GluPhe: 1.734 ± 0.014	3.003GluGly: 3.003 ± 0.02	1.572GluHis: 1.572 ± 0.015	2.33GluIle: 2.33 ± 0.018	2.246GluLys: 2.246 ± 0.019	5.445GluLeu: 5.445 ± 0.028	1.208GluMet: 1.208 ± 0.011	1.496GluAsn: 1.496 ± 0.014	2.768GluPro: 2.768 ± 0.022	2.011GluGln: 2.011 ± 0.016	4.231GluArg: 4.231 ± 0.026	3.45GluSer: 3.45 ± 0.02	2.883GluThr: 2.883 ± 0.018	3.265GluVal: 3.265 ± 0.022	0.912GluTrp: 0.912 ± 0.009	1.406GluTyr: 1.406 ± 0.013	0.0GluXaa: 0.0 ± 0.0
Phe	3.774PheAla: 3.774 ± 0.018	0.58PheCys: 0.58 ± 0.008	2.402PheAsp: 2.402 ± 0.017	1.936PheGlu: 1.936 ± 0.015	1.502PhePhe: 1.502 ± 0.014	2.656PheGly: 2.656 ± 0.023	0.876PheHis: 0.876 ± 0.012	1.629PheIle: 1.629 ± 0.015	1.283PheLys: 1.283 ± 0.013	3.423PheLeu: 3.423 ± 0.02	0.735PheMet: 0.735 ± 0.009	1.236PheAsn: 1.236 ± 0.011	2.188PhePro: 2.188 ± 0.018	1.1PheGln: 1.1 ± 0.009	2.066PheArg: 2.066 ± 0.014	2.887PheSer: 2.887 ± 0.019	2.191PheThr: 2.191 ± 0.016	2.762PheVal: 2.762 ± 0.017	0.602PheTrp: 0.602 ± 0.01	0.96PheTyr: 0.96 ± 0.01	0.0PheXaa: 0.0 ± 0.0
Gly	5.849GlyAla: 5.849 ± 0.026	0.935GlyCys: 0.935 ± 0.012	3.542GlyAsp: 3.542 ± 0.022	3.092GlyGlu: 3.092 ± 0.019	2.365GlyPhe: 2.365 ± 0.015	5.064GlyGly: 5.064 ± 0.042	1.682GlyHis: 1.682 ± 0.014	2.81GlyIle: 2.81 ± 0.02	2.712GlyLys: 2.712 ± 0.02	5.537GlyLeu: 5.537 ± 0.026	1.341GlyMet: 1.341 ± 0.015	1.985GlyAsn: 1.985 ± 0.017	3.447GlyPro: 3.447 ± 0.022	2.104GlyGln: 2.104 ± 0.013	4.19GlyArg: 4.19 ± 0.024	5.134GlySer: 5.134 ± 0.025	4.055GlyThr: 4.055 ± 0.025	4.442GlyVal: 4.442 ± 0.022	1.086GlyTrp: 1.086 ± 0.012	1.673GlyTyr: 1.673 ± 0.015	0.0GlyXaa: 0.0 ± 0.0
His	2.666HisAla: 2.666 ± 0.018	0.426HisCys: 0.426 ± 0.006	1.535HisAsp: 1.535 ± 0.014	1.32HisGlu: 1.32 ± 0.012	0.996HisPhe: 0.996 ± 0.011	1.782HisGly: 1.782 ± 0.014	0.774HisHis: 0.774 ± 0.011	1.333HisIle: 1.333 ± 0.013	0.81HisLys: 0.81 ± 0.009	2.633HisLeu: 2.633 ± 0.019	0.541HisMet: 0.541 ± 0.008	0.761HisAsn: 0.761 ± 0.009	1.867HisPro: 1.867 ± 0.014	0.762HisGln: 0.762 ± 0.009	1.782HisArg: 1.782 ± 0.014	1.9HisSer: 1.9 ± 0.017	1.572HisThr: 1.572 ± 0.013	1.972HisVal: 1.972 ± 0.016	0.413HisTrp: 0.413 ± 0.007	0.65HisTyr: 0.65 ± 0.01	0.0HisXaa: 0.0 ± 0.0
Ile	4.477IleAla: 4.477 ± 0.024	0.658IleCys: 0.658 ± 0.008	2.58IleAsp: 2.58 ± 0.016	2.228IleGlu: 2.228 ± 0.019	1.678IlePhe: 1.678 ± 0.016	2.56IleGly: 2.56 ± 0.018	1.074IleHis: 1.074 ± 0.012	1.963IleIle: 1.963 ± 0.017	1.427IleLys: 1.427 ± 0.015	4.135IleLeu: 4.135 ± 0.025	0.813IleMet: 0.813 ± 0.009	1.24IleAsn: 1.24 ± 0.012	2.859IlePro: 2.859 ± 0.017	1.402IleGln: 1.402 ± 0.012	2.74IleArg: 2.74 ± 0.016	3.186IleSer: 3.186 ± 0.017	2.417IleThr: 2.417 ± 0.018	3.284IleVal: 3.284 ± 0.023	0.734IleTrp: 0.734 ± 0.009	1.064IleTyr: 1.064 ± 0.011	0.0IleXaa: 0.0 ± 0.0
Lys	3.646LysAla: 3.646 ± 0.027	0.465LysCys: 0.465 ± 0.008	2.08LysAsp: 2.08 ± 0.016	2.173LysGlu: 2.173 ± 0.018	1.188LysPhe: 1.188 ± 0.013	2.204LysGly: 2.204 ± 0.016	0.978LysHis: 0.978 ± 0.011	1.545LysIle: 1.545 ± 0.014	2.195LysLys: 2.195 ± 0.022	3.452LysLeu: 3.452 ± 0.023	0.731LysMet: 0.731 ± 0.008	1.118LysAsn: 1.118 ± 0.012	2.188LysPro: 2.188 ± 0.02	1.308LysGln: 1.308 ± 0.012	3.096LysArg: 3.096 ± 0.021	2.504LysSer: 2.504 ± 0.018	2.302LysThr: 2.302 ± 0.017	2.167LysVal: 2.167 ± 0.017	0.537LysTrp: 0.537 ± 0.008	1.022LysTyr: 1.022 ± 0.011	0.0LysXaa: 0.0 ± 0.0
Leu	9.791LeuAla: 9.791 ± 0.037	1.569LeuCys: 1.569 ± 0.014	5.865LeuAsp: 5.865 ± 0.026	5.353LeuGlu: 5.353 ± 0.031	3.417LeuPhe: 3.417 ± 0.021	5.636LeuGly: 5.636 ± 0.027	2.899LeuHis: 2.899 ± 0.022	3.365LeuIle: 3.365 ± 0.021	3.42LeuLys: 3.42 ± 0.021	9.125LeuLeu: 9.125 ± 0.044	1.621LeuMet: 1.621 ± 0.015	2.835LeuAsn: 2.835 ± 0.018	6.678LeuPro: 6.678 ± 0.035	3.765LeuGln: 3.765 ± 0.022	7.445LeuArg: 7.445 ± 0.034	7.613LeuSer: 7.613 ± 0.033	5.15LeuThr: 5.15 ± 0.028	6.517LeuVal: 6.517 ± 0.029	1.459LeuTrp: 1.459 ± 0.012	2.375LeuTyr: 2.375 ± 0.016	0.0LeuXaa: 0.0 ± 0.0
Met	1.822MetAla: 1.822 ± 0.011	0.29MetCys: 0.29 ± 0.005	1.189MetAsp: 1.189 ± 0.012	0.926MetGlu: 0.926 ± 0.009	0.744MetPhe: 0.744 ± 0.009	1.114MetGly: 1.114 ± 0.012	0.597MetHis: 0.597 ± 0.008	0.735MetIle: 0.735 ± 0.01	0.721MetLys: 0.721 ± 0.009	1.977MetLeu: 1.977 ± 0.015	0.426MetMet: 0.426 ± 0.007	0.607MetAsn: 0.607 ± 0.008	1.394MetPro: 1.394 ± 0.014	0.834MetGln: 0.834 ± 0.01	1.581MetArg: 1.581 ± 0.013	1.894MetSer: 1.894 ± 0.013	1.207MetThr: 1.207 ± 0.011	1.091MetVal: 1.091 ± 0.01	0.308MetTrp: 0.308 ± 0.007	0.504MetTyr: 0.504 ± 0.006	0.0MetXaa: 0.0 ± 0.0
Asn	3.301AsnAla: 3.301 ± 0.02	0.4AsnCys: 0.4 ± 0.007	1.699AsnAsp: 1.699 ± 0.013	1.472AsnGlu: 1.472 ± 0.012	1.129AsnPhe: 1.129 ± 0.012	2.395AsnGly: 2.395 ± 0.02	0.627AsnHis: 0.627 ± 0.008	1.553AsnIle: 1.553 ± 0.011	1.004AsnLys: 1.004 ± 0.01	2.726AsnLeu: 2.726 ± 0.018	0.631AsnMet: 0.631 ± 0.008	0.986AsnAsn: 0.986 ± 0.011	1.918AsnPro: 1.918 ± 0.015	0.807AsnGln: 0.807 ± 0.011	1.526AsnArg: 1.526 ± 0.011	2.023AsnSer: 2.023 ± 0.017	1.767AsnThr: 1.767 ± 0.014	2.361AsnVal: 2.361 ± 0.018	0.459AsnTrp: 0.459 ± 0.007	0.755AsnTyr: 0.755 ± 0.01	0.0AsnXaa: 0.0 ± 0.0
Pro	7.074ProAla: 7.074 ± 0.042	0.715ProCys: 0.715 ± 0.008	3.567ProAsp: 3.567 ± 0.019	3.465ProGlu: 3.465 ± 0.022	2.22ProPhe: 2.22 ± 0.014	4.027ProGly: 4.027 ± 0.027	1.665ProHis: 1.665 ± 0.014	2.314ProIle: 2.314 ± 0.016	2.196ProLys: 2.196 ± 0.02	5.574ProLeu: 5.574 ± 0.027	1.093ProMet: 1.093 ± 0.012	1.961ProAsn: 1.961 ± 0.014	6.622ProPro: 6.622 ± 0.056	2.293ProGln: 2.293 ± 0.023	4.361ProArg: 4.361 ± 0.026	6.567ProSer: 6.567 ± 0.041	4.536ProThr: 4.536 ± 0.029	4.232ProVal: 4.232 ± 0.027	0.805ProTrp: 0.805 ± 0.009	1.534ProTyr: 1.534 ± 0.012	0.0ProXaa: 0.0 ± 0.0
Gln	3.198GlnAla: 3.198 ± 0.023	0.505GlnCys: 0.505 ± 0.009	1.77GlnAsp: 1.77 ± 0.015	1.721GlnGlu: 1.721 ± 0.014	1.182GlnPhe: 1.182 ± 0.012	1.911GlnGly: 1.911 ± 0.015	1.176GlnHis: 1.176 ± 0.012	1.417GlnIle: 1.417 ± 0.014	1.219GlnLys: 1.219 ± 0.014	3.644GlnLeu: 3.644 ± 0.02	0.739GlnMet: 0.739 ± 0.01	1.07GlnAsn: 1.07 ± 0.01	2.431GlnPro: 2.431 ± 0.023	2.06GlnGln: 2.06 ± 0.048	2.778GlnArg: 2.778 ± 0.02	2.597GlnSer: 2.597 ± 0.018	2.121GlnThr: 2.121 ± 0.014	2.012GlnVal: 2.012 ± 0.014	0.561GlnTrp: 0.561 ± 0.008	0.979GlnTyr: 0.979 ± 0.009	0.0GlnXaa: 0.0 ± 0.0
Arg	6.903ArgAla: 6.903 ± 0.032	1.05ArgCys: 1.05 ± 0.012	3.768ArgAsp: 3.768 ± 0.018	3.714ArgGlu: 3.714 ± 0.026	2.367ArgPhe: 2.367 ± 0.014	3.893ArgGly: 3.893 ± 0.024	1.832ArgHis: 1.832 ± 0.016	3.187ArgIle: 3.187 ± 0.019	2.827ArgLys: 2.827 ± 0.021	6.705ArgLeu: 6.705 ± 0.03	1.483ArgMet: 1.483 ± 0.012	2.03ArgAsn: 2.03 ± 0.014	4.174ArgPro: 4.174 ± 0.024	2.382ArgGln: 2.382 ± 0.018	6.306ArgArg: 6.306 ± 0.04	5.239ArgSer: 5.239 ± 0.031	4.268ArgThr: 4.268 ± 0.023	4.714ArgVal: 4.714 ± 0.023	1.132ArgTrp: 1.132 ± 0.011	1.644ArgTyr: 1.644 ± 0.014	0.0ArgXaa: 0.0 ± 0.0
Ser	7.805SerAla: 7.805 ± 0.033	1.09SerCys: 1.09 ± 0.012	4.174SerAsp: 4.174 ± 0.024	3.312SerGlu: 3.312 ± 0.022	2.987SerPhe: 2.987 ± 0.019	5.185SerGly: 5.185 ± 0.028	1.972SerHis: 1.972 ± 0.016	3.351SerIle: 3.351 ± 0.019	2.674SerLys: 2.674 ± 0.021	7.54SerLeu: 7.54 ± 0.03	1.573SerMet: 1.573 ± 0.014	2.282SerAsn: 2.282 ± 0.018	5.822SerPro: 5.822 ± 0.037	2.573SerGln: 2.573 ± 0.017	5.36SerArg: 5.36 ± 0.03	8.716SerSer: 8.716 ± 0.053	5.941SerThr: 5.941 ± 0.041	5.142SerVal: 5.142 ± 0.026	1.105SerTrp: 1.105 ± 0.012	1.848SerTyr: 1.848 ± 0.014	0.0SerXaa: 0.0 ± 0.0
Thr	6.043ThrAla: 6.043 ± 0.027	0.912ThrCys: 0.912 ± 0.011	2.878ThrAsp: 2.878 ± 0.016	2.51ThrGlu: 2.51 ± 0.015	2.452ThrPhe: 2.452 ± 0.017	3.917ThrGly: 3.917 ± 0.02	1.577ThrHis: 1.577 ± 0.012	2.786ThrIle: 2.786 ± 0.018	2.016ThrLys: 2.016 ± 0.015	6.328ThrLeu: 6.328 ± 0.029	1.159ThrMet: 1.159 ± 0.01	1.693ThrAsn: 1.693 ± 0.014	4.697ThrPro: 4.697 ± 0.032	1.897ThrGln: 1.897 ± 0.014	3.987ThrArg: 3.987 ± 0.022	5.575ThrSer: 5.575 ± 0.032	4.433ThrThr: 4.433 ± 0.031	4.28ThrVal: 4.28 ± 0.021	0.892ThrTrp: 0.892 ± 0.01	1.503ThrTyr: 1.503 ± 0.014	0.0ThrXaa: 0.0 ± 0.0
Val	6.698ValAla: 6.698 ± 0.026	1.093ValCys: 1.093 ± 0.013	4.224ValAsp: 4.224 ± 0.022	3.819ValGlu: 3.819 ± 0.023	2.665ValPhe: 2.665 ± 0.018	3.815ValGly: 3.815 ± 0.021	1.96ValHis: 1.96 ± 0.015	2.732ValIle: 2.732 ± 0.019	2.542ValLys: 2.542 ± 0.019	6.949ValLeu: 6.949 ± 0.034	1.307ValMet: 1.307 ± 0.012	1.96ValAsn: 1.96 ± 0.016	4.47ValPro: 4.47 ± 0.023	2.668ValGln: 2.668 ± 0.018	4.428ValArg: 4.428 ± 0.022	4.867ValSer: 4.867 ± 0.026	3.92ValThr: 3.92 ± 0.021	5.152ValVal: 5.152 ± 0.03	1.086ValTrp: 1.086 ± 0.01	1.792ValTyr: 1.792 ± 0.017	0.0ValXaa: 0.0 ± 0.0
Trp	1.317TrpAla: 1.317 ± 0.013	0.247TrpCys: 0.247 ± 0.005	1.011TrpAsp: 1.011 ± 0.013	0.801TrpGlu: 0.801 ± 0.01	0.577TrpPhe: 0.577 ± 0.008	0.807TrpGly: 0.807 ± 0.01	0.407TrpHis: 0.407 ± 0.006	0.74TrpIle: 0.74 ± 0.008	0.691TrpLys: 0.691 ± 0.008	1.427TrpLeu: 1.427 ± 0.012	0.369TrpMet: 0.369 ± 0.006	0.633TrpAsn: 0.633 ± 0.009	0.768TrpPro: 0.768 ± 0.009	0.53TrpGln: 0.53 ± 0.009	1.236TrpArg: 1.236 ± 0.012	1.173TrpSer: 1.173 ± 0.011	1.121TrpThr: 1.121 ± 0.012	0.879TrpVal: 0.879 ± 0.01	0.29TrpTrp: 0.29 ± 0.006	0.403TrpTyr: 0.403 ± 0.007	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.418TyrAla: 2.418 ± 0.016	0.414TyrCys: 0.414 ± 0.007	1.643TyrAsp: 1.643 ± 0.013	1.319TyrGlu: 1.319 ± 0.013	1.046TyrPhe: 1.046 ± 0.012	1.789TyrGly: 1.789 ± 0.016	0.625TyrHis: 0.625 ± 0.009	1.172TyrIle: 1.172 ± 0.012	0.895TyrLys: 0.895 ± 0.01	2.344TyrLeu: 2.344 ± 0.016	0.54TyrMet: 0.54 ± 0.008	0.901TyrAsn: 0.901 ± 0.009	1.404TyrPro: 1.404 ± 0.014	0.777TyrGln: 0.777 ± 0.009	1.56TyrArg: 1.56 ± 0.012	1.804TyrSer: 1.804 ± 0.014	1.558TyrThr: 1.558 ± 0.014	1.641TyrVal: 1.641 ± 0.013	0.432TyrTrp: 0.432 ± 0.007	0.765TyrTyr: 0.765 ± 0.01	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 26313 proteins (9701046 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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